sodium bicarbonate

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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GENERIC NAME: sodium bicarbonate

BRAND NAME: Alka-Seltzer Heartburn Relief

DRUG CLASS AND MECHANISM: Sodium bicarbonate is an alkalinizing agent (antacid) that reduces stomach acid. It is a commonly used antacid to treat heartburn, acid ingestion and upset stomach. Oral sodium bicarbonate provides rapid relief (within 15 minutes) of heartburn symptoms and should only be used to provide temporary relief of occasional episodes of stomach acid problems. Oral administration of sodium bicarbonate results in the neutralization of hydrochloric acid in the stomach (raises blood and urinary pH) and the formation of sodium chloride, carbon dioxide, and water.

PRESCRIPTION: No

GENERIC AVAILABLE: Yes

PREPARATIONS: Effervescent granules for oral solution: 460 mg. Oral tablet: 325 and 650 mg

STORAGE: Store at room temperature 59 C - 86 C (15 F – 30 F).

PRESCRIBED FOR: Oral sodium bicarbonate is used for the temporary relief of occasional episodes of acid ingestion, heartburn, and upset stomach.

DOSING: Oral antacid: 325 mg to 2 g 1-4 times per day.

DRUG INTERACTIONS: Sodium bicarbonate may increase the blood concentration of flecainide (Tambocor) by increasing the pH of urine, leading to less excretion of flecainide.

Sodium bicarbonate may decrease blood concentration of amphetamines, atazanavir (Reyataz), bisacodyl (Dulcolax), captopril (Capoten), dabigatran (Pradaxa), itraconazole (Sporanox) and many other drugs.

Medically Reviewed by a Doctor on 10/13/2014

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