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- Patient Comments: SIBO - Causes
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Who is at risk for SIBO?
Small intestine bowel overgrowth is often associated with another illness that affects the function of the small intestine. The body has many protective mechanisms to keep bacteria under control, including stomach acidity and intestinal motility, the ability for the intestine to move its contents downstream at an appropriate speed. Bacterial growth is hindered by the presence of bile and immunoglobulins. Finally, the ileocecal valve prevents stool from refluxing from the colon (large intestine) into the ileum or the last part of the small intestine.
Any illness or disease that affects the body's defense mechanism puts a person at risk for SIBO, but the majority of people develop SIBO because of an intestinal motility problem. These may include complications from gastric bypass surgery, bowel strictures and adhesions that can lead to intermittent bowel obstructions, diverticuli or outpouchings of the small intestine, and tumors. Bowel motility may be affected by neurologic diseases including myotonic dystrophy and Parkinson's disease. People with diabetes with autonomic dysfunction (nerve damage) may also develop dysmotility.
Other intestinal diseases that may be associated with SIBO include:
- Crohn's disease
- Celiac disease
- Achlorhydria (chronic inflammation causes the stomach to become unable to produce acid)
- Cirrhosis of the liver
- Alcohol abuse
- Non-alcoholic steatohepatitis (NASH)