sitagliptin; Januvia (cont.)
Omudhome Ogbru, PharmD
Medical and Pharmacy Editor:
SIDE EFFECTS AND PRECAUTIONS: The most common side effects of sitagliptin are:
Other important side effects of sitagliptin include:
There have been reports of fatal and non-fatal pancreatitis following use of sitagliptin. Acute kidney failure and severe hypersensitivity reactions have also been reported during treatment with sitagliptin.
GENERIC AVAILABLE: No
PREPARATIONS: Tablets: 25, 50, and 100 mg
STORAGE: Tablets should be stored at room temperature, 15-30 C (59-86 F)
DOSING: Sitagliptin may be taken with or without food. The recommended dose is 100 mg once daily. Renal function should be assessed prior to starting sitagliptin and periodically during treatment. The dose of sitagliptin should be modified based on renal function.
DRUG INTERACTIONS: Sitagliptin may slightly increase the concentration of digoxin (Lanoxin) in the body when both drugs are being taken. Digoxin concentrations should be monitored appropriately. The occurrence of low blood glucose increases when sitagliptin is combined with a sulfonylurea (for example, glyburide [Micronase, Diabeta, Glynase, Prestab]) or insulin. The dose of insulin or sulfonylurea should be reduced.
PREGNANCY: There are no adequate studies of sitagliptin in pregnant women.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 12/24/2014
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