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- What is sitagliptin, and how does it work (mechanism of action)?
- What brand names are available for sitagliptin?
- Is sitagliptin available as a generic drug?
- Do I need a prescription for sitagliptin?
- What are the side effects of sitagliptin?
- What is the dosage for sitagliptin?
- Which drugs or supplements interact with sitagliptin?
- Is sitagliptin safe to take if I'm pregnant or breastfeeding?
- What else should I know about sitagliptin?
What is sitagliptin, and how does it work (mechanism of action)?
Sitagliptin is an oral drug that reduces blood sugar (glucose) levels in patients with type 2 diabetes. Sitagliptin is a member of a class of drugs that inhibit the enzyme, dipeptidyl peptidase-4 (DPP-4) and are therefore called DPP-4 inhibitors. Other members of the class include saxagliptin (Onglyza) and linagliptin (Tradjenta) Following a meal, incretin hormones such as glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are released from the intestine, and their levels increase in the blood. GLP-1 and GIP reduce blood glucose by increasing the production and release of insulin from the pancreas. GLP-1 also reduces blood glucose by reducing the secretion by the pancreas of the hormone, glucagon, a hormone that increases the production of glucose by the liver and raises the blood level of glucose. The net effect of increased release of GLP-1 and GIP is to reduce blood glucose levels. Sitagliptin inhibits the enzyme, DPP-4, that destroys GLP-1 and GIP and thereby increases the levels and activity of both hormones. As a result, blood glucose levels fall. In summary, sitagliptin reduces blood glucose levels by inhibiting DPP-4 and increasing the levels of GLP-1 and GIP. Sitagliptin was approved by the FDA in October 2006.
What brand names are available for sitagliptin?
Is sitagliptin available as a generic drug?
GENERIC AVAILABLE: No
Do I need a prescription for sitagliptin?
What are the side effects of sitagliptin?
AND PRECAUTIONS The most common side effects of sitagliptin are:
Other important side effects of sitagliptin include:
There have been reports of fatal and non-fatal pancreatitis following use of sitagliptin. Acute kidney failure and severe hypersensitivity reactions have also been reported during treatment with sitagliptin.
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