Zocor (simvastatin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PREPARATIONS:

  • Tablets: 5, 10, 20, 40, and 80 mg.
  • Orally disintegrating tablets: 10, 20, 40, and 80 mg.

DRUG INTERACTIONS: Decreased elimination of simvastatin could increase the levels of simvastatin in the body and increase the risk of muscle toxicity from simvastatin. Examples of drugs that decrease elimination of simvastatin include

They should not be combined with simvastatin.

Large quantities of grape fruit juice (>1 quart daily) also will increase blood levels of simvastatin and should be avoided.

The following drugs should not be used with simvastatin:

Patients taking amiodarone, amlodipine, or ranolazine should not exceed 20 mg, and patients taking verapamil or diltiazem should not exceed 10 mg of of simvastatin daily. Patients taking gemfibrozil or danazol should not take simvastatin.

Simvastatin increases the effect of warfarin (Jantoven, Coumadin) and the blood concentration of digoxin (Lanoxin). Patients taking simvastatin and warfarin or digoxin should be monitored carefully.

Cholestyramine (Questran) decreases the absorption of ezetimibe (Zetia); Therefore, simvastatin should be taken 2 hours before or at least 4 hours after cholestyramine.

Chinese patients taking ≥1 g/day of niacin in combination with simvastatin 40 mg have an increased risk of muscle-related side effects. Therefore, these patients should not receive simvastatin 80 mg combined with niacin in doses ≥1 g/day. Simvastatin doses greater than 20 mg daily should be administered cautiously when combined with niacin ≥1 g/day.

Medically Reviewed by a Doctor on 7/12/2016

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