simeprevir, Olysio

Medical and Pharmacy Editor:

GENERIC NAME: simeprevir


DRUG CLASS AND MECHANISM: Simeprevir is an oral, direct-acting an-tiviral agent used for treating infections with the hepatitis C virus (HCV). boceprevir (Victrelis), telaprevir (Incivek), and sofosbuvir (Sovaldi) are other direct-acting drugs for treating HCV. Simeprevir blocks the effect of pro-teases which are enzymes that HCV needs for making new viruses, leading to reduced numbers of HCV in the body. Simeprevir is effective for treating people infected with HCV genotype 1, including those with liver disease. The FDA approved simeprevir in November 2013.



PREPARATIONS: Capsules: 150 mg

STORAGE: Capsules should be stored at room temperature below 30 C (86 F).

PRESCRIBED FOR: Simeprevir is used in combination with ribavirin (Rebetol, Copegus) and peginterferon to treat infections with HCV.

DOSING: The recommended dose of simeprevir is one 150 mg capsule once daily with or without food for 12 weeks in combination with peginter-feron and ribavarin.

DRUG INTERACTIONS: Rifampin and St. John's wort may reduce blood levels of simeprevir by increasing its metabolism (break-down) in the intestine. Therefore, simeprevir should not be combined with rifampin or St. John's wort. Other drugs that also may reduce blood levels of simeprevir include carbamazepine (Tegretol, Tegretol XR , Equetro, Carbatrol), phenytoin (Dilantin, Dilantin-125),  phenobarbital, oxcarbazepine (Tripetal), rifabutin, rifampin, rifapentine (Prifitin), efavirenz (Sustiva), nevirapine (Viramune, Viramune XR), and etravirine (Intelence).

Medically Reviewed by a Doctor on 1/23/2014

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