Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
GENERIC NAME: simeprevir
BRAND NAME: Olysio
DRUG CLASS AND MECHANISM: Simeprevir is an oral, direct-acting an-tiviral agent used for treating infections with the hepatitis C virus (HCV). Boceprevir (Victrelis), telaprevir (Incivek), and sofosbuvir (Sovaldi) are other direct-acting drugs for treating HCV. Simeprevir blocks the effect of pro-teases which are enzymes that HCV needs for making new viruses, leading to reduced numbers of HCV in the body. Simeprevir is effective for treating people infected with HCV genotype 1, including those with liver disease. The FDA approved simeprevir in November 2013.
GENERIC AVAILABLE: No
PREPARATIONS: Capsules: 150 mg
STORAGE: Capsules should be stored at room temperature below 30 C (86 F).
PRESCRIBED FOR: Simeprevir is used in combination with ribavirin (Rebetol, Copegus) and peginterferon to treat infections with HCV.
DOSING: The recommended dose of simeprevir is one 150 mg capsule once daily with or without food for 12 weeks in combination with peginter-feron and ribavarin.
DRUG INTERACTIONS: Rifampin and St. John's wort may reduce blood levels of simeprevir by increasing its metabolism (break-down) in the intestine. Therefore, simeprevir should not be combined with rifampin or St. John's wort. Other drugs that also may reduce blood levels of simeprevir include carbamazepine (Tegretol, Tegretol XR , Equetro, Carbatrol), phenytoin (Dilantin, Dilantin-125), phenobarbital, oxcarbazepine (Tripetal), rifabutin, rifampin, rifapentine (Prifitin), efavirenz (Sustiva), nevirapine (Viramune, Viramune XR), and etravirine (Intelence).
Antibiotics such as erythromycin and clarithromycin reduce breakdown of simeprevir in the liver, increasing blood levels of simeprevir and its side effects. The antifungal drugs ketoconazole (Nizoral, Extina, Xolegel, Kuric) and itraconazole (Sporanox) also have a similar effect.
PREGNANCY: Simeprevir has not been adequately evaluated in pregnant women. However, ribavarin which is combined with simeprevir should not be used by pregnant women or their male partners.
NURSING MOTHERS: It is not known if simeprevir is secreted into breast milk.
REFERENCE: FDA.gov prescribing information. simeprevir.
Last Editorial Review: 1/23/2014 1:44:22 PM
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