Sickle Cell Disease
(Sickle Cell Anemia)

Medical Author: William C. Shiel Jr., MD, FACP, FACR

• What is sickle cell anemia?
• How is sickle cell anemia inherited?
• What conditions promote the sickling (distortion) of the red blood cells in sickle cell anemia?
• How is sickle cell anemia diagnosed?
• What are the symptoms and treatments of sickle cell anemia?
• What is the outlook (prognosis) for patients with sickle cell anemia?
• Sickle Cell Anemia At A Glance
• Patient Discussions: Sickle Cell Disease (Sickle Cell Anemia) - Describe Your Experience

What is sickle cell anemia?

Sickle cell anemia (sickle cell disease) is a disorder of the blood caused by an inherited abnormal hemoglobin (an oxygen-carrying protein within the red blood cells). The abnormal hemoglobin causes distorted (sickled) red blood cells. The sickled red blood cells are fragile and prone to rupture. When the number of red blood cells decreases from rupture (hemolysis), anemia is the result. This condition is referred to as sickle cell anemia. The irregular sickled cells can also block blood vessels causing tissue and organ damage and pain.

Sickle cell anemia is one of the most common inherited blood anemias. The disease primarily affects Africans and African Americans. It is estimated that in the United States, some 50,000 African Americans are afflicted with the most severe form of sickle cell anemia. Overall, current estimates are that one in 1,875 U.S. African American is affected with sickle cell anemia.

Sickle Cell Disease (Sickle Cell Anemia) - Describe Your Experience

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