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The Cleveland Clinic

Multiple Chemical Sensitivity

What Is Multiple Chemical Sensitivity?

Multiple chemical sensitivity (MCS) is the name given by some to a condition in which various symptoms reportedly appear after a person has been exposed to any of a wide range of chemicals. The exposure may occur as a major event, such as a chemical spill, or from long-term contact with low-levels of chemicals, such as in an office with poor ventilation. As a result of exposure, people with MCS develop sensitivity and have reactions to the chemicals even at levels most people can tolerate.

Other names for this condition are "environmental illness" and "sick building syndrome."

bIs MCS a Real Disorder?

Many recognized medical groups and societies, including the CDC, the American Medical Association, and the American Academy of Allergy, Asthma and Immunology, do not consider MCS a distinct physical disorder. There are several reasons for this.

First, there is a lack of clinical evidence to support a physical cause for the symptoms. In addition, people with MCS do not develop antibodies in response to chemical exposure, as is the case with an immune system, or allergic, reaction. Further, people with MCS also have high rates of mental health disorders, including depression, anxiety, and somatoform disorders -- mental disorders that are expressed through physical symptoms. About 50% of people with MCS meet the criteria for depression and/or anxiety disorders. Much of the controversy, then, centers on whether the symptoms associated with MCS are caused by physical or psychological factors.



Next: What are the symptoms of multiple chemical sensitivity (sick building syndrome)? »

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What is a depressive disorder?

Depressive disorders have been with mankind since the beginning of recorded history. In the Bible, King David, as well as Job, suffered from this affliction. Hippocrates referred to depression as melancholia, which literally means black bile. Black bile, along with blood, phlegm, and yellow bile were the four humors (fluids) that described the basic medical physiology theory of that time. Depression, also referred to as clinical depression, has been portrayed in literature and the arts for hundreds of years, but what do we mean today when we refer to a depressive disorder? In the 19th century, depression was seen as an inherited weakness of temperament. In the first half of the 20th century, Freud linked the development of depression to guilt and conflict. John Cheever, the author and a modern sufferer of depressive disorder, wrote of conflict and experiences with his parents as influencing his development of depression.

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