- What are SGLT2 inhibitors?
- What generic and brand names of SGLT2 inhibitors are available in the US?
- Do I need a prescription for SGLT2 inhibitors?
- Why are of SGLT2 inhibitors prescribed to patients?
- What are the side effects of SGLT2 inhibitors?
- Which drugs or supplements interact with SGLT2 inhibitors?
- Are of SGLT2 inhibitors safe to take during pregnancy or while breastfeeding?
- What preparations of SGLT2 inhibitors are available?
- How do SGLT2 inhibitors work?
What are SGLT2 inhibitors?
SGLT2 (sodium-glucose co-transporter 2) inhibitors are prescription oral medications used to treat type 2 diabetes.
What generic and brand names of SGLT2 inhibitors are available in the US?
Brand and generic names of SGLT2 inhibitors and combination products that contain SGLT2 inhibitors include:
- canagliflozin (Invokana)
- dapagliflozin (Farxiga)
- empagliflozin (Jardiance)
- empagliflozin/linagliptin (Glyxambi)
- empagliflozin/metformin (Synjardy)
- dapagliflozin/metformin (Xigduo XR)
Do I need a prescription for SGLT2 inhibitors?
Why are of SGLT2 inhibitors prescribed to patients?
- SGLT2 inhibitors are used alone or in combination with metformin or other diabetic medications and with exercise and diet to reduce blood glucose in adults with type 2 diabetes.
- SGLT2 inhibitors are not for treating people with type 1 diabetes or for treating diabetic ketoacidosis.
- SGLT2 inhibitors are not prescribed for patients with kidney disease including those on dialysis.
What are the side effects of SGLT2 inhibitors?
The most common side effect of SGLT2 inhibitors include:
- Genital yeast infections in men and women
- Urinary tract infections (UTIs)
- Increased urination
- Kidney problems
- Flu like symptoms
- Nasal congestion
- Urinary discomfort
- Back pain
Serious side effects of SGLT2 inhibitors include:
- Kidney failure
- Hyperkalemia (high levels of potassium in the blood)
- Hypotension (low blood pressure)
- Increased cholesterol levels
- Serious urinary tract infections
- Increased bladder cancer risk
- Serious allergic reactions
- Low blood glucose (hypoglycemia) when combined with insulin or drugs that increase insulin production
On May 15, 2015, the FDA informed the public that SGLT2 inhibitors have been associated with increased risk of ketoacidosis in people with diabetes.
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