Severe Acute Respiratory Syndrome (SARS) (cont.)

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What are risk factors for SARS?

SARS-CoV can infect a person regardless of their health status or age group. However, it was clear that some people were at increased risk during the 2002 outbreak. This included people over the age of 50 (some reported mortality rates of about 50%), pregnant women, and those with underlying diabetes, heart disease, or liver disease. A major risk factor is simply a close association with any person infected with SARS-CoV since the virus is easily spread through droplets spewed into the air.

What are SARS symptoms and signs?

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Symptoms begin two to 14 days after acquiring the virus. Initially, the illness resembles influenza with fever and a mild cough. The breathing disorder often progresses to severe shortness of breath (dyspnea) and inability to maintain oxygenation (hypoxia). Progression may be rapid or it may take several days. Severely affected people develop a potentially fatal form of respiratory failure, known as adult respiratory distress syndrome (ARD or ARDS). In addition to the attacking the alveoli in the lungs, the virus also infects other organs in the body, causing reduced white blood cell counts (lymphopenia), inflammation of the arteries (vasculitis), and inflammation of the gut with diarrhea.

Reviewed by Charles Patrick Davis, MD, PhD on 6/9/2011

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