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What causes microscopic colitis?
The cause(s) of microscopic colitis is unknown. Some experts suspect that
microscopic colitis is an autoimmune disorder similar to the autoimmune
disorders that cause chronic ulcerative colitis and Crohn's disease.
One study has implicated long term (longer than 6 months) use of
nonsteroidal antiinflammatory drugs (NSAIDs) as a cause of microscopic colitis.
Some individuals' diarrhea improves after stopping the NSAIDs. Serveral other
drugs have also been incriminated as a cause of microscopic colitis. The most
common are proton pump inhibitors (PPIs) such as lansoprazole (Prevacid,
Prevacid SoluTab), omeprazole (Prilosec, Zegerid), and esomeprazole (Nexium);
the Statin simvastatin (Zocor); H2 blocker ranitidine (Zantac); SSRI sertraline
Zoloft); and P2Y12 inhibitor ticlopidine (Tilcid).