Microscopic Colitis - Treatments

Not ready to share? Read other Patient Comments

What was the treatment for your lymphocytic colitis?

Share your story with others:

MedicineNet appreciates your comment. Your comment may be displayed on the site and will always be published anonymously.Patient Comments FAQs

Enter your Comment

Tell us a bit about your background to make your comments more useful to other MedicineNet users. (Optional)

Screen Name: *

Gender of Patient: Male Female

Age Range of Patient:

I am a: Patient Caregiver

* Screen Name will appear next to the published comment. Please do not include your full name or email address.

By submitting your comment, and other materials (collectively referred to as a "Submission") to MedicineNet, you grant MedicineNet permission to use, copy, transmit, publish, display, edit and modify your Submission in connection with its Web site. MedicineNet will not pay you for your Submission. You represent that you have all rights necessary for MedicineNet to use your Submission as set forth above.

Please keep these guidelines in mind when writing your comment:

  • Please make sure you address the question asked.
  • Due to the overwhelming number of comments received, not all comments will be published.
  • When selecting comments to publish, our staff will choose those that are educational and complement the topic. Please try to stay on topic.
  • Your comment may be edited. We would typically edit comments to make them clearer and more readable. We will remove personal information such as last names, email and web addresses, and other potentially harmful information.
  • We will not notify you if your comment has been published. We suggest that you check back on the topic article regularly.
  • We do not provide medical or healthcare advice, treatment, or diagnosis.

Thank you for participating!

I have read and agree to abide by the MedicineNet Terms and Conditions and the MedicineNet Privacy Policy (required).

To prevent our systems from spam, please complete the following prior to submitting your comment.

Please select the black square:

What is the treatment for microscopic colitis?

The treatment of microscopic colitis has not been standardized because there have not been adequate large scale, prospective, placebo controlled treatment trials. The following strategies are safe and may relieve diarrhea in some patients:

  • Avoid nonsteroidal anti-inflammatory drugs (NSAIDs) and the other drugs mentioned under causes of microscopic colitis.
  • Trial of lactose elimination (just to eliminate the possibility that intolerance to lactose in milk is aggravating the diarrhea)
  • Antidiarrhea agents such as loperamide (Imodium) or diphenoxylate and atropine (Lomotil)
  • Bismuth subsalicylate (Pepto-Bismol)
  • budesonide (Entocort EC)
  • 5-ASA (mesalamine) compounds such as Asacol, Pentasa, or Colazal

Controlled trials showed that budesonide (Entocort, a poorly absorbed steroid) is effective in controlling diarrhea in more than 75% of the patients with collagenous colitis, but the diarrhea tends to recur soon after stopping Entocort.

Though data supporting their use is lacking, some doctors may use medications that potently suppress the immune system such as azathioprine (Imuran, Azasan) and 6-mercaptopurine in patients with severe microscopic colitis that is unresponsive to other treatments.

Return to Microscopic Colitis (Lymphocytic Colitis and Collagenous Colitis)

See what others are saying

Comment from: Terry, 55-64 Female (Patient) Published: March 06

I was diagnosed with C. difficile colitis 6 months ago. Before I was diagnosed I had been feeling very poorly. I was experiencing overwhelming fatigue and diarrhea. I had gone to several doctors who said I was over worked and depressed and I needed to see a psychiatrist. It was a nightmare! I decided to see my gastroenterologist. The day after I saw my gastroenterologist I became very ill with a very high fever and I became dehydrated and had to be hospitalized. The diagnosis in the hospital was bacterial colitis which was treated with antibiotics. I was in the hospital for two weeks. About three weeks after I left the hospital I went back to my gastroenterologist and he told me I had C. difficile/microscopic colitis. He gave me hyoscyamine 0.125mg for cramps and suggested I use Imodium for the diarrhea and slowly introduce more solid foods into my diet. About 5 weeks ago I began to have the colitis symptoms again and went back to him and he put me on the low FODMAP diet. I have been on the diet and eliminated all gluten and lactose products from my diet and it is getting a little better. I no longer experience diarrhea but now I get constipated and have to drink 1/4 of a (10oz) bottle of magnesium citrate so I can have a bowel movement. I have lost 20lbs in six months. I also experience pain in the center and left regions of the upper abdomen as well as my upper and lower back.

Was this comment helpful?Yes
Comment from: kW girl, 55-64 Female (Patient) Published: May 22

I was diagnosed with lymphocytic colitis in February 2014. I went on an 8 week course of Uceris. Within 24 hours my diarrhea had subsided. Six weeks after I stopped taking the drug my diarrhea returned, but I am now back on Uceris with the same result. Great drug but very expensive.

Was this comment helpful?Yes


Get the latest health and medical information delivered direct to your inbox!