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Microscopic Colitis - Treatments

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What was the treatment for your lymphocytic colitis?

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What is the treatment for microscopic colitis?

The treatment of microscopic colitis has not been standardized because there have not been adequate large scale, prospective, placebo controlled treatment trials. The following strategies are safe and may relieve diarrhea in some patients:

  • Avoid nonsteroidal antiinflammatory drugs (NSAIDs)

  • Trial of lactose elimination (just to eliminate the possibility that intolerance to lactose in milk is aggravating the diarrhea)

  • Antidiarrhea agents such as loperamide (Imodium) or diphenoxylate and atropine (Lomotil)

  • Bismuth subsalicylate such as Pepto-Bismol

  • budesonide (Entocort EC)

  • 5-ASA (mesalamine) compounds such as Asacol, Pentasa, or Colazal

Controlled trials showed that budesonide (Entocort, a poorly absorbed steroid) is effective in controlling diarrhea in more than 75% of the patients with collagenous colitis, but the diarrhea tends to recur soon after stopping Entocort.

Though data supporting their use is lacking, some doctors may use medications that potently suppress the immune system such as azathioprine (Imuran, Azasan) and 6-mercaptopurine in patients with severe microscopic colitis that is unresponsive to other treatments.

Return to Microscopic Colitis (Lymphocytic Colitis and Collagenous Colitis)

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Comment from: psalms18, 45-54 Female (Patient) Published: February 10

Hi just thought I would give my two cents on this topic. I have MC both with LC first then CC/LC. I tried the asacol, butrine, and the pepto tablets. The asacol made me so sick so quit, Butrine worked until I quit taking it, pepto worked for a while then my body just ignored it. Prednisone was the wonder drug but not a good thing to stay on. So started up after I quit steroids. I have had this going on 16 years. Mine is the liquid type, I have found quite a bit of relief with a gluten free diet and no milk (lactose) cheese ok and yogurt no. I did the probiotics before they were the new thing and it was just ok. Imodium doesn't work and I can take up to 5 or so and nothing but helps with the cramps. But I do notice that when I am not eating gluten I do not get the intense cramping. Yes I still have watery stools. I take easily digested vitamins and make sure I keep hydrated. Yes, I still get easily fatigued but learn to pace myself or be exhausted and I do mean EXHAUSTED. Hope this helps.

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Comment from: donna, 45-54 Female (Patient) Published: August 24

I just recently was diagnosed with microscopic colitis. I have had bouts of explosive diarrhea for 20 years or more and have been told years ago that it was IBS or diverticulitis, or many other things. I always had to know where the closest bathroom was, or be able to pull off the road. Since the colonoscopy everything has been normal. I just hope it stays that way. So I can't see how the colonoscopy could of started it. It helped me.... Good luck!!

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