Pernicious Anemia - Treatments

Not ready to share? Read other Patient Comments

What was the effective treatment for you pernicious anemia?

Share your story with others:

MedicineNet appreciates your comment. Your comment may be displayed on the site and will always be published anonymously.Patient Comments FAQs

Enter your Comment

Tell us a bit about your background to make your comments more useful to other MedicineNet users. (Optional)

Screen Name: *

Gender of Patient: Male Female

Age Range of Patient:

I am a: Patient Caregiver

* Screen Name will appear next to the published comment. Please do not include your full name or email address.

By submitting your comment, and other materials (collectively referred to as a "Submission") to MedicineNet, you grant MedicineNet permission to use, copy, transmit, publish, display, edit and modify your Submission in connection with its Web site. MedicineNet will not pay you for your Submission. You represent that you have all rights necessary for MedicineNet to use your Submission as set forth above.

Please keep these guidelines in mind when writing your comment:

  • Please make sure you address the question asked.
  • Due to the overwhelming number of comments received, not all comments will be published.
  • When selecting comments to publish, our staff will choose those that are educational and complement the topic. Please try to stay on topic.
  • Your comment may be edited. We would typically edit comments to make them clearer and more readable. We will remove personal information such as last names, email and web addresses, and other potentially harmful information.
  • We will not notify you if your comment has been published. We suggest that you check back on the topic article regularly.
  • We do not provide medical or healthcare advice, treatment, or diagnosis.

Thank you for participating!

I have read and agree to abide by the MedicineNet Terms and Conditions and the MedicineNet Privacy Policy (required).

To prevent our systems from spam, please complete the following prior to submitting your comment.

Please select the black square:

What is the treatment for pernicious anemia and vitamin B-12 deficiency?

The symptoms of pernicious anemia and vitamin B-12 deficiency can be treated by replenishing the vitamin B-12 supply in the body. If a condition other than pernicious anemia is responsible for vitamin B-12 deficiency, treatment also must be directed at the underlying condition. Symptoms of vitamin B-12 deficiency may be improved after just a few days of medical treatment.

Vitamin B-12 is typically given as an intramuscular injection (shot). An injection of 1000 micrograms (1 mg) of vitamin B-12 is generally given every day for one week, followed by 1 mg every week for four weeks and then 1 mg every month thereafter.

Alternative treatments for pernicious anemia include high-dose oral vitamin B-12, since a lower-efficiency absorption system for vitamin B-12 exists in the intestine that does not require the presence of IF. However, the oral dose required for this type of therapy (1 to 2 milligrams/day) is more than 200 times higher than the minimum daily vitamin B-12 requirement for adults and is significantly higher than that available in most standard multivitamins and B-12 supplements. Nasal spray and sublingual (under the tongue) preparations of vitamin B-12 also are available and are under investigation.

Return to Pernicious Anemia

See what others are saying

Comment from: 55-64 Female (Patient) Published: January 20

B-12 injections. I am African American female correctly diagnosed with Pernicious Anemia atage 23. At 14 years, Army physicians (military dependant) thought I had Iron deficiency and Rx iron supplements and eating liver. Crisis at 23, So. California Hematologist diagnosed me with PA after a 2 week hospital stay. Because of my age and visual ethnicity physicians did not think PA deficiency. Being 8th generation American, physicians did not take into consideration any European ancestry. Monthly B-12 injections have helped for over 30 years. During pregnancy and 1st year of Motherhood-additional B-12 injections were given. Occasionally, injection does not work. After entire battery of tests, another injection was administered and it worked. This happens, but rarely. During routine colonoscopy, I was informed individuals with PA have a 4 fold increase in the possibility of stomach cancer. An endoscopy preformed at the same time as colonoscopy, showed 5 stomach polyps. A biopsy of polyps proved malignant. I have had two additional endoscopies removing more polyps. GI physician says I can probably expect to have more endoscopies in the future. I have always been a-symptomatic-occasionally some parenthesia.

Was this comment helpful?Yes
Comment from: bb1985, Female (Patient) Published: August 20

I have pernicious anemia. I have been taking vitamin B12 Injections and they worked great. Now I cannot get the vitamin B12, my husband gave me a shot every 2 weeks, and I am worried. I started taking the one you put under your tongue, and I don't know if it works or not; the doctor told me, with pernicious anemia I would have to have the shots.

Was this comment helpful?Yes


Get the latest health and medical information delivered direct to your inbox!

Health Solutions From Our Sponsors