Primary Sclerosing Cholangitis - Medications

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What medications were helpful with the symptoms you experienced with primary sclerosing cholangitis?

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There is no medication that is approved to treat primary sclerosing cholangitis, but medications may be used to control symptoms. Ursodiol (Actigal), also known as ursodeoxycholic acid (UDCA), may improve liver function tests but has not been shown to increase survival and may be associated with complications like bleeding. While it is thought that PSC may be an autoimmune disease, immunosuppressive medications have not been shown to work.

Itching is often treated with antihistamines including diphenhydramine (Benadryl), hydroxyzine (Atarax) and cyproheptadine (Periactin). Cholestyramine (Questran, Questran Light), a medication that helps bind bile salts may also be helpful.

Should infection occur, treatment may require antibiotics.

As the disease progresses, the damaged liver may not be able to help with the absorption of vitamins and nutrients from the intestine. Vitamins and other dietary and calorie supplements may be required to treat malnutrition.

Return to Primary Sclerosing Cholangitis (PSC)

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Comment from: sundance, 55-64 Male (Patient) Published: October 14

I was prescribed ursodiol upon diagnosis of primary sclerosing cholangitis in 2006 and have been using it ever since. Since taking it I have not experienced another septic episode. However, my most recent MRI did reveal a new stricture in my bile duct which confirms that ursodiol does not impede progression of the disease.

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