Liver - Medications

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What medications caused inflammation of the liver? What was the treatment?

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Liver disease causes (medications, toxins, genetics, cancer, and others)

Medications or drug induced liver inflammation

Liver inflammation is a relatively common side effect of medications. Some commonly prescribed medications include the following:

  • acetaminophen over the counter (Tylenol, Panadol) but also in prescription pain medications (hydrocodone/acetaminophen (Lortab, Vicodin, Norco)
  • Statins (medications used to control elevated blood cholesterol levels)
  • Antibiotics (amoxiciilin-clavulinic acid [Augmentin, Augmentin XR], nitrofurantoin [Macrodantin, Furadantin, Macrobid], tetracycline, isoniazid)
  • methotrexate (Trexall, Rheumatrex)
  • disulfiram (Antabusel)
  • Herbal remedies, for example, kava kava, mahuang, comfrey

Toxins

  • Poisonous mushrooms may damage the liver and cause liver failure.
  • Alcohol in large doses can be toxic for the liver and damages the liver over time.
  • Aflatoxins produced by certain fungi are toxic to the liver
  • Industrial chemicals may be toxins that affect the liver, such as arsenic and carbon tetrachloride

Genetic disorders

Genetic disorders can affect the liver, examples include the following:

  • Hemochromatosis with abnormal iron storage
  • Wilson's Disease with abnormal copper storage
  • Gilbert's Disease with abnormal bilirubin metabolism

Cancer

  • Primary liver cancers arise directly from cells within the liver.
  • Metastatic liver disease describes cancer that arises from another organ and invades the liver

Abnormalities of bile flow from the liver

Abnormalities of bile flow from the liver may lead to liver inflammation, for example:

  • Gallstones (the most common disease)
  • Primary biliary cirrhosis
  • Primary sclerosing cholangitis.

Decrease in blood flow draining from the liver

Decrease in blood flow draining out of the liver may cause the liver to become congested and inflamed, two examples include:

  • Congestive heart failure (CHF) is a condition in which the heart is not strong enough to pump all of the blood it receives, and that blood can back up into the liver.
  • Budd Chiari syndrome is a disease in which blood clots form in the hepatic veins, preventing blood from leaving the liver.
Return to Liver (Anatomy and Function)

See what others are saying

Comment from: stovall, 35-44 Female (Caregiver) Published: July 21

My daughter age 35 just got back from the doctor. She's been having nausea, vomiting, abdominal pain, bleeding through her bowels a lot (2 inches small intestine taken out), and diarrhea. She had a hysterectomy 1 year ago. Then they found polyps in her bowel, and cancer cells. Today exam before surgery showed 2 abnormalities on her liver. She has never been an alcohol drinker, but is bi-polar and doctor says her medications may have caused this. She has no hepatitis. They have to scrape or remove 2 spots to know what it is.

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