Antimitichondrial Antibodies - Patient Experience

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Did you test positive for antimitochondrial antibodies? How did your treatment progress after that point?

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What are antimitochondrial antibodies (AMA)?

Between 95 and 98% of patients with primary biliary cirrhosis (PBC) have autoantibodies (antibodies to self) in their blood that react with the inner lining of mitochondria. These autoantibodies are called antimitochondrial antibodies (AMA). Mitochondria are the energy factories present inside all of our cells, not just the cells of the liver or bile ducts. (The mitochondria use the oxygen carried in the blood from the lungs as a fuel to generate energy.) AMA actually bind to protein antigens that are contained in multienzyme complexes (packages of enzymes) within the inner lining of the mitochondria. These multienzyme complexes produce key chemical reactions necessary for life. The complexes are referred to as multienzyme because they are made up of multiple enzyme units.

AMA specifically react against a component of this multienzyme complex called E2. In PBC, AMA preferentially react with the E2 component of one of the multienzymes that is called the pyruvate dehydrogenase complex (PDC). Accordingly, the antigen is designated as PDC-E2. The practical importance of all of this is that the PDC-E2 antigen is now used, as discussed below, in a diagnostic test for PBC. The PDC-E2 antigen is also referred to as M2, a term introduced to designate it as the second mitochondrial antigen discovered by researchers interested in PBC.

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Comment from: maggiep, 55-64 Female (Patient) Published: January 20

Antimitochondrial antibodies were found in me by chance when I was found to have fibromyalgia. Nothing has ever been done since I was diagnosed (4 years ago). But only today I saw a new doctor who says she intends to do a liver function test every 6 months. I should mention my father died from hepatitis in 1991 and they now think it is passed through genes.

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Comment from: kimilie907, 55-64 Female (Patient) Published: April 14

I have been having stroke-like events for over 20 years, I am 56. I was diagnosed with ichthyosis at an early age, but was not told what kind. I have been having dystonia, hemiparesis, and various other issues. Doctors suspected MS (multiple sclerosis), but forced the issue. Negative. But I tested positive for AMA (antimitochondrial) M2, two times. Still my doctors are ignoring my symptoms, they would much rather believe it's all psychological and gave me crazy papers 10 years ago. I moved recently, looking to hook up with a doctor who knows something.

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