Antiphospholipid Syndrome - Tests

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Describe the tests you've had to detect antiphospholipid antibodies and antiphospholipid syndrome.

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What laboratory tests can support the diagnosis of antiphospholipid syndrome?

Patients with the antiphospholipid syndrome can have a variety of antibodies to molecules called phospholipids in their blood. These antibodies include VDRL/RPR (a syphilis test that can be falsely positive in these patients), lupus anticoagulant, prolonged PTT, beta 2 glycoprotein I antibodies, and anticardiolipin antibody. As mentioned above, the anticardiolipin antibody has also been found in patients with the immune disease systemic lupus erythematosus, which is characterized by the production of a variety of abnormal antibodies.

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Comment from: survivor hemet, 55-64 Female (Patient) Published: May 01

I have had repeated deep vein thrombosis (DVT) post knee surgery. Only recently did my primary physician send me for tests to detect antiphospholipid antibodies. In February the lab drew 7 vials of blood. The test came back positive for antiphospholipid syndrome. In April my physician sent me for a second round of testing. The lab drew 10 vials of blood, testing positive again. The diagnosis can only be made after 2 positive test results in a 3 month period.

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