Rhabdomyolysis - Describe Your Experience

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What is rhabdomyolysis?

Rhabdomyolysis (RAB-DOE-MY-O-LIE-SIS) is the rapid destruction of skeletal muscle resulting in leakage into the urine of the muscle protein myoglobin.

There are three different types of muscle in the human body;

  1. smooth muscle,
  2. skeletal muscle, and
  3. heart muscle.

The skeletal muscle is the muscle of movement of the body (moving the skeleton at the joints). Skeletal muscle is affected by rhabdomyolysis.

Myoglobin is a protein component of the muscle cells that is released into the blood when the skeletal muscle is destroyed in rhabdomyolysis. Creatine kinase is an enzyme (a protein that facilitates chemical reactions in the body) also in the muscle cells. The level of each of these proteins can be measured in blood to monitor the degree of muscle injury from rhabdomyolysis. Myoglobin can also be measured in samples of urine.

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See what others are saying

Comment from: Mountain Biker, 35-44 Male (Patient) Published: June 29

I have been an endurance mountain biker for roughly 7 years. We had a kid, I rode a lot less, but still entered into events (8 hour 100 mile races). The last one went fine, slower due to my lack of riding, but I was not sore the following two days, then muscle pain and tenderness started. I noticed two small darker colored urine, but dismissed this as slight dehydration. Finally I tested for rhabdomyolysis, which was confirmed. I have been known for my 'off the couch' performance, guess it has caught up to me. I hope riding more prior to events, and training will help ensure I do not experience this again (2 weeks to naturally flush my system).

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Comment from: Kate2515, 65-74 Female (Patient) Published: July 26

I am a diabetic and have hypothyroid. I also take statins but have been on the same one for 13 years. My doctor prescribed phentermine to help me lose weight. I had taken it for a few days with no problem. Then one day I went to dinner with friends and had a few drinks. After about 3 or 4 hours, I took Xanax which I take for sleep. I woke up and couldn't move and realized I was in insulin shock (this has happened before and I recognized the symptoms, although not as bad as this). I could not move except for my right leg where I was trying to get my purse, which had candy in it. I just couldn't do it. Several hours later, my boss came over and found me semi-conscious and took me to the emergency room where they diagnosed me with hypoglycemia associated with diabetes rhabdomyolysis (my glucose was 32). I didn't want to be admitted, so the doctor told me it was most likely due to be being in one position for hours and advised me to drink a lot of water. I stopped taking phentermine because after doing a little research, I found out that phentermine can cause low blood sugar. It took almost two weeks before I finally felt better.

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