Angelman Syndrome - Signs and Symptoms

Not ready to share? Read other Patient Comments

What were the signs and symptoms associated with your child's Angelman syndrome?

Share your story with others:

MedicineNet appreciates your comment. Your comment may be displayed on the site and will always be published anonymously.Patient Comments FAQs

Enter your Comment

Tell us a bit about your background to make your comments more useful to other MedicineNet users. (Optional)

Screen Name: *

Gender of Patient: Male Female

Age Range of Patient:

I am a: Patient Caregiver

* Screen Name will appear next to the published comment. Please do not include your full name or email address.

By submitting your comment, and other materials (collectively referred to as a "Submission") to MedicineNet, you grant MedicineNet permission to use, copy, transmit, publish, display, edit and modify your Submission in connection with its Web site. MedicineNet will not pay you for your Submission. You represent that you have all rights necessary for MedicineNet to use your Submission as set forth above.

Please keep these guidelines in mind when writing your comment:

  • Please make sure you address the question asked.
  • Due to the overwhelming number of comments received, not all comments will be published.
  • When selecting comments to publish, our staff will choose those that are educational and complement the topic. Please try to stay on topic.
  • Your comment may be edited. We would typically edit comments to make them clearer and more readable. We will remove personal information such as last names, email and web addresses, and other potentially harmful information.
  • We will not notify you if your comment has been published. We suggest that you check back on the topic article regularly.
  • We do not provide medical or healthcare advice, treatment, or diagnosis.

Thank you for participating!

I have read and agree to abide by the MedicineNet Terms and Conditions and the MedicineNet Privacy Policy (required).

To prevent our systems from spam, please complete the following prior to submitting your comment.

Please select the black triangle:

What are the characteristics, signs, and symptoms of Angelman syndrome?

  • Infants with Angelman syndrome appear normal at birth, but often have feeding problems in the first months of life and exhibit noticeable developmental delays by 6 to 12 months.
  • Seizures often begin between 2 and 3 years of age.
  • Speech impairment is pronounced, with little to no use of words. Individuals with this syndrome often display the following that can have severe functional deficits:
    • hyperactivity,
    • small head size,
    • sleep disorders,
    • movement and balance disorders
  • Children with Angelman syndrome typically have a happy, excitable demeanor with frequent smiling, laughter, and hand-flapping movements.
  • In addition to hyperactivity, a short attention span, and a fascination with water are common.
  • With age, people with Angelman syndrome become less excitable, and the sleeping problems tend to improve. However, affected individuals continue to have intellectual disability, severe speech impairment, and seizures throughout their lives.
  • Adults with Angelman syndrome have distinctive facial features that may be described as "coarse." Other common features include unusually fair skin with light-colored hair and an abnormal side-to-side curvature of the spine (scoliosis). The life expectancy of people with this condition appears to be nearly normal.

Angelman syndrome results from absence of a functional copy of the UBE3A gene inherited from the mother.

Return to Angelman Syndrome

See what others are saying

Comment from: JANEEN, 25-34 Female (Caregiver) Published: October 06

My daughter is 28 years old and was diagnosed 10 years ago with Angelman syndrome. She has a 48 degree of scoliosis with 2 curves in her spinal cord which helps her in a way to still be mobile to a certain degree. She has no speech and makes loud screaming noises when excited. When she was younger she smiled and laughed a lot, not so much now. She also had a fascination for water when she was younger. She wants to hug everyone and seems not to know her own strength because her grip is very powerful. She is very lovable and I wish there was something I could do to help her. My heart aches for her each day. I wish medical science can discover a cure for her.

Was this comment helpful?Yes


Get the latest health and medical information delivered direct to your inbox!