Hemophilia - Signs and Symptoms

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What were the signs and symptoms of hemophilia in you or someone you know?

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What are the signs and symptoms of hemophilia?

Hemophilia can vary in its severity, depending upon the particular type of mutation (genetic defect). The degree of symptoms depends upon the levels of the affected clotting factor. Severe disease is defined as <1% factor activity, 1% to 5% factor activity is moderate disease, and greater than 5% factor activity constitutes mild disease. The extent of bleeding is dependent upon the severity (the amount of factor activity) and is similar for hemophilia A and B.

With severe hemophilia (A or B), bleeding begins at an early age and may occur spontaneously. Those with mild hemophilia may only bleed excessively in response to injury or trauma. Female carriers of hemophilia have variable degrees of factor activity; some may have near normal levels and do not show any bleeding tendencies, while some may have less than the predicted 50% reduction and may bleed more often than non-carrier females.

In severe hemophilia, bleeding episodes usually begin within the first 2 years of life. Heavy bleeding after circumcision in males is sometimes the first sign of the condition. Symptoms may develop later in those with moderate or mild disease. The bleeding of hemophilia can occur anywhere in the body. Common sites for bleeding are the joints, muscles, and gastrointestinal tract. Specific sites and types of bleeding are discussed below.

  • Hemarthrosis (bleeding into the joints) is characteristic of hemophilia. The knees and ankles are most often affected. The bleeding causes distension of the joint spaces, significant pain, and over time, can be disfiguring. Over time, joint destruction occurs, and joint replacement surgeries can be required.
  • Bleeding into the muscles may occur withhematoma formation (compartment syndrome).
  • Bleeding from the mouth or nosebleeds may occur. Bleeding after dental procedures is common, and oozing of blood from the gums may occur in young children when new teeth are erupting.
  • Bleeding from the gastrointestinal tract can lead to blood in the stool.
  • Bleeding from the urinary tract can lead to blood in the urine (hematuria).
  • Intracranial hemorrhage (bleeding into the brain or skull) can lead to symptoms such as nausea, vomiting, and/or lethargy.
  • Increased bleeding after surgery or trauma is characteristic of hemophilia.
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Comment from: *jega, 7-12 Male (Caregiver) Published: January 30

Over bleeding from the teeth is the first symptom. Hemophilia most of time attacks men. It is a genetic problem. Pain in the joints and head ache are some of the symptoms of hemophilia. In hemophilia injecting the plasma factor is the one of the treatment.

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