NDM-1 - Treatment

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What treatments or medications did you receive for an infection caused by NDM-1?

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What is the treatment for an infection caused by bacteria that make NDM-1?

Treatment is guided by the antibiotic resistance pattern. Many NDM-1 strains are resistant to all antibiotics except for colistin and tigecycline. Colistin is an older antibiotic that has not been used much in recent decades, because it is somewhat more toxic than other antibiotics. A few NDM-1 strains have been sensitive to tigecycline (Tygacil), but this agent should be used cautiously in serious infections because it does not achieve high levels in the bloodstream. A few strains have also been sensitive to aztreonam, although the U.S. strains were not. Researchers have identified a new antibiotic compound that may inhibit NDM-1 containing bacterial topoisomerase function so the bacterial replication is inhibited or stopped. Unfortunately, the compound has not gone through any clinical trials and is not commercially available.

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Comment from: kissmyasthma27, 19-24 Male (Patient) Published: November 07

I received Colistin (polymyxin E) and tigecycline.

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