If you have severe scalp psoriasis, which prescription medications have you tried?
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What are systemic treatments for psoriasis?
If the scalp is involved as part of severe psoriasis deemed too extensive to be treated practically with topical medications, then medications delivered orally or by injection may be necessary. All these medications comprise more risk when compared to topical medication. They include oral drugs like methotrexate (Rheumatrex, Trexall), cyclosporine (Sandimmune), acitretin (Soriatane), apremilast (Otezla), and some of the so-called biological drugs that are administered by infusion into a vein (infliximab [Remicade]) or by injection into the deeper layers of the skin like etanercept (Enbrel), adalimumab (Humira), ustekinumab (Stelara), and secukinumab (Cosentyx). Regular laboratory work is often necessary to monitor for the toxicities associated with some of these systemic therapies.