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What causes PMDD?
Although the precise cause of PMS and PMDD is unknown, it is believed that
these conditions result from the interaction of hormones produced by the ovaries
at different stages in the menstrual cycle (such as estrogen and progesterone)
with the neurotransmitters (chemicals that serve as messengers) in the brain.
While the ovarian hormone levels are normal in women with PMDD, it is likely
that the brain's response to these normally-fluctuating hormone levels is
Most evidence suggests that PMS and PMDD do not result from any specific
personality traits or personality types. While stress clearly is associated with
PMS and PMDD, it is not considered to be a cause of PMDD. Rather, the associated
stress is more likely to be a result of the PMS or PMDD symptoms. Vitamin or
other nutritional deficiencies have not been shown to cause PMS or PMDD.