Tylenol Liver Damage - Signs and Symptoms

What were the signs and symptoms of Tylenol-induced liver damage in you or someone you know?

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What are the symptoms and signs of acetaminophen-induced liver damage?

Three clinical stages (phases) of acetaminophen-induced liver injury have been described.

During the first phase, that is, the initial 12 to 24 hours or so after ingestion, the patient experiences nausea and vomiting.

For the next perhaps 12 to 24 hours, which is the second phase or the so-called inactive (latent) phase, the patient feels well.

In the third phase, which begins about 48 to as late as 72 hours after the ingestion of acetaminophen, liver blood test abnormalities begin to appear. Most notably, extremely high (abnormal) levels of the liver blood tests, AST and ALT, are common with this type of liver injury. The outcome (prognosis) of the liver injury can be predicted fairly accurately on the basis of the patient's clinical exam and blood tests. For example, at one extreme, if the patient develops severe acid buildup in the blood, kidney failure, bleeding disorders, or coma, then death is almost certain. Only a liver transplant can possibly save such a patient.

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