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Treatment and Outcomes
Most cases of sporotrichosis only involve the skin and/or subcutaneous tissues and are non-life-threatening, but the infection requires treatment with prescription antifungal medication for several months. The most common treatment for this type of sporotrichosis is oral itraconazole for 3 to 6 months. Itraconazole may also be used to treat bone and joint infections, but treatment should continue for at least 12 months.
For patients with severe disease, and/ or an infection that has spread throughout the body, a lipid formulation of amphotericin B should be used. Itraconazole can be used for step-down therapy once the patient has stabilized. Supersaturated potassium iodide (SSKI) is another treatment option for cutaneous or lymphocutaneous disease. SSKI and azole drugs like itraconazole should not be used during pregnancy. Treatment recommendations may differ for children.