Aseptic Necrosis - Cause

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What causes aseptic necrosis?

Aseptic necrosis can be caused by trauma and damage to the blood vessels that supply bone its oxygen. Other causes of poor blood circulation to the bone include a blockage by air or fat (embolism) that obstructs the blood flow through the blood vessels, abnormally thick blood (hypercoagulable state), atherosclerosis (hardening of the arteries), or inflammation of the blood vessel walls (vasculitis). Steroid medications (cortisone, such as prednisone [Deltasone, Liquid Pred] and methylprednisolone [Medrol, Depo-Medrol]) are the most common medications to cause aseptic necrosis. Typical bones affected by steroids include the femur bone of the hip, the humerus bone of the shoulder, and the tibia bone of the knee, sometimes in combinations and frequently affecting both sides of the body (bilateral). Aseptic necrosis of the jawbone has been associated with the use of medications (bisphosphonates) used to treat high blood calcium levels from cancer.

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See what others are saying

Comment from: 2young4this, 35-44 Male (Patient) Published: April 14

I have avascular necrosis (AVN) of the femur, probably the result of a nearly 18 month run of small intestine bacterial overgrowth.

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Comment from: Artlover70, 65-74 Female (Patient) Published: May 01

My necrosis was caused by prednisone, a necessity for my kidney transplant eight years ago. I have had one hip replaced and have spider fractures in the other and both knees.

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