Aseptic Necrosis - Cause

Not ready to share? Read other Patient Comments

What do you think was the cause of your aseptic necrosis?

Share your story with others:

MedicineNet appreciates your comment. Your comment may be displayed on the site and will always be published anonymously.Patient Comments FAQs

Enter your Comment

Tell us a bit about your background to make your comments more useful to other MedicineNet users. (Optional)

Screen Name: *

Gender of Patient: Male Female

Age Range of Patient:

I am a: Patient Caregiver

* Screen Name will appear next to the published comment. Please do not include your full name or email address.

By submitting your comment, and other materials (collectively referred to as a "Submission") to MedicineNet, you grant MedicineNet permission to use, copy, transmit, publish, display, edit and modify your Submission in connection with its Web site. MedicineNet will not pay you for your Submission. You represent that you have all rights necessary for MedicineNet to use your Submission as set forth above.

Please keep these guidelines in mind when writing your comment:

  • Please make sure you address the question asked.
  • Due to the overwhelming number of comments received, not all comments will be published.
  • When selecting comments to publish, our staff will choose those that are educational and complement the topic. Please try to stay on topic.
  • Your comment may be edited. We would typically edit comments to make them clearer and more readable. We will remove personal information such as last names, email and web addresses, and other potentially harmful information.
  • We will not notify you if your comment has been published. We suggest that you check back on the topic article regularly.
  • We do not provide medical or healthcare advice, treatment, or diagnosis.

Thank you for participating!

I have read and agree to abide by the MedicineNet Terms and Conditions and the MedicineNet Privacy Policy (required).

To prevent our systems from spam, please complete the following prior to submitting your comment.

Please select the white triangle:

What causes aseptic necrosis?

Aseptic necrosis can be caused by trauma and damage to the blood vessels that supply bone its oxygen. Other causes of poor blood circulation to the bone include a blockage by air or fat (embolism) that obstructs the blood flow through the blood vessels, abnormally thick blood (hypercoagulable state), atherosclerosis (hardening of the arteries), or inflammation of the blood vessel walls (vasculitis). Steroid medications (cortisone, such as prednisone [Deltasone, Liquid Pred] and methylprednisolone [Medrol, Depo-Medrol]) are the most common medications to cause aseptic necrosis. Typical bones affected by steroids include the femur bone of the hip, the humerus bone of the shoulder, and the tibia bone of the knee, sometimes in combinations and frequently affecting both sides of the body (bilateral). Aseptic necrosis of the jawbone has been associated with the use of medications (bisphosphonates) used to treat high blood calcium levels from cancer.

Return to Aseptic Necrosis

See what others are saying

Comment from: ziggy, 55-64 Male (Patient) Published: September 15

My avascular necrosis (AVN) or aseptic necrosis was most likely caused by heavy prednisone use over the last 5 years due to COPD. I am a former smoker and was diagnosed with emphysema in my late 30s. I stopped smoking immediately and COPD was well managed for over 20 years by diet, exercise and occasional medication. The last 5 years however have required daily medication and frequent heavy steroid use as the exacerbations are occurring with greater frequency and lasting longer. Prednisone is a miracle for lung disease patients but is a major cause of AVN.

Was this comment helpful?Yes
Comment from: Richwood, 65-74 Female (Patient) Published: May 06

I had severe trauma to my right thigh fifty years ago. I developed severe burning pain in my thigh due to a nerve problem, meralgia paresthetica, and while getting an MRI for that the doctor found the entire femur has avascular necrosis. I never smoked but have been overweight most of my life. I had a knee replacement and everything was diagnosed after I did not recover as expected. I think my weight and bad knee caused my avascular necrosis.

Was this comment helpful?Yes


Get the latest health and medical information delivered direct to your inbox!

Health Solutions From Our Sponsors