Alpha-1 Antitrypsin Deficiency: Symptoms

Not ready to share? Read other Patient Comments

What symptoms did you experience with alpha-1 antitrypsin deficiency? How old were you when they appeared?

Share your story with others:

MedicineNet appreciates your comment. Your comment may be displayed on the site and will always be published anonymously.Patient Comments FAQs

Enter your Comment

Tell us a bit about your background to make your comments more useful to other MedicineNet users. (Optional)

Screen Name: *

Gender of Patient: Male Female

Age Range of Patient:

I am a: Patient Caregiver

* Screen Name will appear next to the published comment. Please do not include your full name or email address.

By submitting your comment, and other materials (collectively referred to as a "Submission") to MedicineNet, you grant MedicineNet permission to use, copy, transmit, publish, display, edit and modify your Submission in connection with its Web site. MedicineNet will not pay you for your Submission. You represent that you have all rights necessary for MedicineNet to use your Submission as set forth above.

Please keep these guidelines in mind when writing your comment:

  • Please make sure you address the question asked.
  • Due to the overwhelming number of comments received, not all comments will be published.
  • When selecting comments to publish, our staff will choose those that are educational and complement the topic. Please try to stay on topic.
  • Your comment may be edited. We would typically edit comments to make them clearer and more readable. We will remove personal information such as last names, email and web addresses, and other potentially harmful information.
  • We will not notify you if your comment has been published. We suggest that you check back on the topic article regularly.
  • We do not provide medical or healthcare advice, treatment, or diagnosis.

Thank you for participating!

I have read and agree to abide by the MedicineNet Terms and Conditions and the MedicineNet Privacy Policy (required).

To prevent our systems from spam, please complete the following prior to submitting your comment.

Please select the white triangle:

What are the signs and symptoms of lung disease caused by alpha-1 antitrypsin deficiency?

The first signs and symptoms of lung disease caused by alpha-1 antitrypsin deficiency usually appear between ages 20 and 50. The earliest symptoms are:

  • shortness of breath following mild activity,
  • reduced ability to exercise, and
  • wheezing.

Other signs and symptoms can include:

  • unintentional weight loss,
  • recurring respiratory infections,
  • fatigue,
  • rapid heartbeat upon standing, and
  • vision abnormalities.

Advanced lung disease leads to emphysema, in which small air sacs in the lungs (alveoli) are damaged. Characteristic features of emphysema include:

  • difficulty breathing,
  • a hacking cough, and
  • a barrel-shaped chest.

Smoking or exposure to tobacco smoke accelerates the appearance of symptoms and damage to the lungs.

About 10 percent of infants and 15 percent of adults with alpha-1 antitrypsin deficiency have liver damage. Signs of liver disease can include:

  • a swollen abdomen,
  • swollen feet or legs, and
  • yellowing of the skin and whites of the eyes (jaundice).

In rare cases, alpha-1 antitrypsin deficiency also causes a skin condition known as panniculitis, which is characterized by hardened skin with painful lumps or patches. Panniculitis varies in severity and can occur at any age.

Return to Alpha-1 Antitrypsin Deficiency

See what others are saying

Comment from: pravin, 19-24 Male (Patient) Published: June 12

It's been a year and I couldn't get a bit of relief from chronic bronchitis caused by alpha-1 antitrypsin deficiency. And since 4 or 5 months, I can hear wheezing, and even a person next to me can hear as well. The doctor is treating me with same medication over and over again. I am having shortness of breath problem. I am so sick of this.

Was this comment helpful?Yes
Comment from: Tracy, 45-54 Male (Patient) Published: November 03

I was first diagnosed with alpha-1 antitrypsin deficiency when I was 42. I had pneumonia and it just wouldn't go away. We did the tests and found out I was ZZ alpha-1 sufferer.

Was this comment helpful?Yes


Get the latest health and medical information delivered direct to your inbox!

Health Solutions From Our Sponsors