Antiphospholipid Syndrome - Effective Treatments

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What kinds of treatment have been effective for your antiphospholipid syndrome?

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How is antiphospholipid syndrome treated?

The treatment of patients with anticardiolipin syndrome has substantially evolved since they were discovered to be clinically important in the mid-1980s. Each manifestation of the antiphospholipid syndrome, and each individual patient with the condition, is treated uniquely.

Because many of the features of illness with anticardiolipin syndrome are associated with an abnormal grouping of normal blood clotting elements (platelets), treatment is often directed toward preventing clotting by thinning the blood. Patients with this disorder have a tendency to form blood clots (thrombosis). The unwanted blood clotting can affect the function of virtually any organ. Medications that thin (anticoagulate) the blood, such as heparin (Hep-Lock, Liquaemin) and warfarin (Coumadin) (powerful blood thinners), are used for treatment. Aspirin has an affect on platelets that inhibits their grouping (aggregation) and has also been used in low doses to thin the blood of selected patients. Cortisone-related medications, such as prednisone, have been used to suppress the immune activity and inflammation in patients with certain features of the condition. For patients with systemic lupus erythematosus who also have antiphospholipid syndrome, hydroxychloroquine (Plaquenil) has been reported to add some protection against blood clotting.

Other reported treatments include the use of intravenous gamma globulin for selected patients with histories of premature miscarriage and those with low blood-clotting elements (platelets) during pregnancy. Recent research studies, however, suggest that intravenous gamma globulin may be no more effective than a combination of aspirin and heparin.

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Comment from: Martha, 65-74 Female (Patient) Published: October 15

I have been diagnosed with Primary Antiphospholipid Syndrome since over 10 years back. I am required to be put in the hospital and put on heparin which I believe has been the best medication until I return to a 3.0 to 4.0 INR. It usually takes 10 to 14 days in the hospital to achieve this point.

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