Amyloidosis - Treatment

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What is the treatment for amyloidosis?

The treatment of amyloidosis depends on the type of amyloidosis involved. Initial treatment of amyloidosis involves correcting organ failure and treating any underlying illness (such as myeloma, infection, or inflammation). The disease is frequently discovered after significant organ damage has already occurred. Therefore, stabilization of organ function is an initial target of treatment. The most frequent cause of death in systemic amyloidosis is kidney failure.

Treatment includes chemotherapy agents usually used for certain cancers and dexamethasone for its anti-inflammatory actions.

Sephardic Jews and Turks inherit a genetic disease called familial Mediterranean fever, which is associated with amyloidosis and characterized by episodes of "attacks" of fever, joint, and abdominal pains. These attacks can be prevented with the medication colchicine (Colcrys). Armenians and Ashkenazi Jews also have a higher incidence of familial Mediterranean fever attacks but do not suffer amyloid deposition disease. Other reports of amyloidosis in families are extremely rare.

Patients with primary amyloidosis who have reasonable underlying health can be treated with a cancer chemotherapy medication (melphalan [Alkeran]) in conjunction with bone-marrow stem-cell transplantation. These treatments attack the abnormal plasma cells in the bone marrow that are causing the primary amyloidosis. The results have been promising, and this combination treatment is offered to eradicate the amyloidosis in selected patients, provided that the underlying medical condition of the patient is adequate. These aggressive treatment options with stem-cell transplantation and high doses of chemotherapy are a true breakthrough in the treatment of patients with this form of amyloidosis.

Familial ATTR amyloidosis can now be cured with liver transplantation. This treatment option requires an accurate diagnosis of the specific protein that causes the disease.

Renal amyloidosis can be treated by kidney transplantation (renal transplantation).

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See what others are saying

Comment from: dianna, 45-54 Female (Patient) Published: July 31

I was diagnosed with amyloidosis in June 2013 after seeing my doctor with a lump in my stomach. The lump turned out to be a much enlarged liver. My oncologist tried low dose chemotherapy with Velcade, dexamethasone, and Cytoxan. This was initially to be 3 weeks on and one week off followed by an autologous stem cell transplant in November or December. By the 3rd week of August my liver was deteriorating quickly and my doctor decided we needed to go to transplant immediately. It took 3 weeks for my stem cells to start growing in the hospital and months of recovery, but a year later I am in remission and feeling better every week.

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Comment from: Rachelle, 55-64 Female (Patient) Published: October 21

Combination of cyclophosphamide, Velcade and dexamethasone, along with Lasix and various anti-nausea, anti-heartburn etc. pills have helped my amyloidosis. I have been in remission for almost 10 months. No transplants because of cardiac involvement.

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