Hepatitis B - Describe Your Experience

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What is hepatitis?

The term 'hepatitis' simply means inflammation of the liver. Hepatitis may be caused by a virus or a toxin such as alcohol. Other viruses that can cause injury to liver cells include the hepatitis A and hepatitis C viruses. These viruses are not related to each other or to hepatitis B virus and differ in their structure, the ways they are spread among individuals, the severity of symptoms they can cause, the way they are treated, and the outcome of the infection.

What is the scope of the problem?

Hepatitis B is an infection of the liver caused by the hepatitis B virus (HBV). It is estimated that 350 million individuals worldwide are infected with the virus, which causes 620,000 deaths worldwide each year. According to the Centers for Disease Control (CDC), approximately 43,000 new cases of hepatitis B occurred in the United States in 2007.

In the United States, rates of new infection were highest among people aged 25 to 44 years (3.1 cases per 100,000 population) and lowest among those younger than 15 years of age (0.02 per 100,000). This reflects the major modes of transmission of hepatitis B (sexual transmission, illicit drug use, exposure to infected blood) and the effect of universal vaccination of infants. In the United States, there has been a 82% decrease in newly diagnosed cases of hepatitis B since 1990. This decrease is attributed to increased vaccination and to heightened public awareness of HIV/AIDS and the resulting safer sexual practices.

When a person first gets hepatitis B, they are said to have an 'acute' infection. Most people are able to eliminate the virus and are cured of the infection. Some are not able to clear the virus and have 'chronic' infection with hepatitis B that is usually life-long (see below). In the United States an estimated 800,000 to 1.4 million people are chronically infected with hepatitis B.

Hepatitis B is found throughout the world. Some countries have much higher rates of infection than the United States; for example, in Southeast Asia and Sub-Saharan Africa, as many as 15% to 20% of adults are chronically infected with hepatitis B.

What kind of a virus is hepatitis B?

The hepatitis B virus is a DNA virus, meaning that its genetic material is made up of deoxyribonucleic acids. It belongs to a family of viruses known as Hepadnaviridae. The virus is primarily found in the liver but is also present in the blood and certain body fluids.

Hepatitis B virus consists of a core particle (central portion) and a surrounding envelope (outer coat). The core is made up of DNA and the core antigen (HBcAg). The envelope contains the surface antigen (HBsAg). These antigens are present in the blood and are markers that are used in the diagnosis and evaluation of patients with suspected viral hepatitis.

How does hepatitis B virus cause liver injury?

The hepatitis B virus reproduces in liver cells, but the virus itself is not the direct cause of damage to the liver. Rather, the presence of the virus triggers an immune response from the body as the body tries to eliminate the virus and recover from the infection. This immune response causes inflammation and may seriously injure liver calls. Therefore, there is a balance between the protective and destructive effects of the immune response to the hepatitis B virus.

Return to Hepatitis B (HBV, Hep B)

See what others are saying

Comment from: Vikas, Male (Patient) Published: February 02

I am carrying hepatitis B virus since long time. I used to donate blood years back. I never had this kind of disease but I am a passive carrier of this virus. Doctors said no medication will help.

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Comment from: StupidBoy, 45-54 Male (Patient) Published: August 24

Nearly 30 years ago, when I was in my late teens I found out I had hepatitis B. If this wasn't bad enough, I then discovered I was a chronic carrier some months later. Previous to this, by a few months, I tested positive for HIV. My world fell apart, but I soon realized I had no one else to blame but myself, as I had numerous sexual partners. I have remained remarkably well this past 30 years, although I was told my liver was in distress, 10 years after I was first diagnosed, and had resisted any treatment until then. I was given Truvada and a couple of other medicines that worked together, akin as a double pronged attack on the viruses, which have swapped and changed over the years because of minor side effects, but a further 10 years on everything is in check health wise and side effects of my illnesses. Only in the last 5 years or so I have suffered fatigue and muscular problems, but yet regular checkups say both the potentially deadly viruses are suppressed and controlled, with only minor blips here and there. I can't grumble at this! I am still generally healthy and alive somehow! I write this so someone may be given a positive vibe from this, and realize hepatitis B is not a death sentence, even when the odds are stacked against you. You can still live a normal, healthy life, even if you have HIV and chronic hepatitis. I know, I have had 30 years' experience to prove it. I wish you well.

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