Pernicious Anemia - Share Your Experience

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What was the cause of your megaloblastic (pernicious) anemia? Please share your experience.

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What is megaloblastic anemia?

Sometimes, anemias are subclassified based upon the size and microscopic appearance of the red blood cells. In this regard, pernicious anemia is a form of megaloblastic anemia. Megaloblastic anemia refers to an abnormally large type of red blood cell (megaloblast). Megaloblasts are produced in the bone marrow when vitamin B-12 or folic acid levels are low. Megaloblastic anemia can also be caused by other disease of the bone marrow and can be a side effect of some cancer chemotherapy drugs.

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See what others are saying

Comment from: MayoPatient, 55-64 Female (Patient) Published: April 11

I was diagnosed with pernicious anemia (PA) about a year ago. B12 was <70. After a loading dose of B12 shots 5 days in a row, once a week for 4 weeks I then started getting shots once a month. After a few months, I could tell I was going downhill. My B12 level was again below normal. Now I get a shot every two weeks and feel so much better. If you feel that your shot doesn"t get you through the month, have your B12 level checked before you get your next shot. You have to be your own advocate. Get shots often enough to get your B12 level up to around 400. Also consider taking iron supplements because iron is hard to absorb.

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Comment from: sbuxt44, 55-64 Female (Patient) Published: October 14

This disease was passed down to me from my mother, her mother, and further back, all Irish. I only gave birth to 3 sons and am hoping it will end there for future progeny. It was held at bay by eating raw calf liver or blood (and no, we are not vampires) but they all had earlier than average mortality, usually around 50 to 60 years if age. One condition of note is that my red blood cells are much larger than normal, when doctor did extensive research. I wonder if it really is pernicious anemia or the large red blood cells which is the cause.

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