What methods of treatment, including medication, have you received for hepatitis C?
Share your story with others:
MedicineNet appreciates your comment. Your comment may be displayed on the site and will always be published anonymously.
What medications cure hepatitis C infection?
Interferons and pegylated interferons such as Peg-Intron A, Pegasys, Roferon,
and Infergen, were mainstays of treatment for years and produced sustained viral
response (SVR, or cure) of up to 50%-80%. These drugs were injected, had many
adverse effects, required frequent monitoring, and were often combined with oral
ribavirin, which caused anemia. Treatment durations ranged up to 48 weeks.
Direct-acting agents (DAA) are antiviral drugs that act directly on hepatitis
They are taken by mouth, are well-tolerated, and cure over 90%
Treatment time is much shorter.
The earliest options were
sofosbuvir (Sovaldi) and simeprevir (Olysio). These were approved by the Food
and Drug Administration (FDA) in 2013.
Ledipasvir and sofosbuvir (Harvoni)
followed as a once-a-day combination pill, in 2014.
With this combination of
DAAs, about 94%-99% of people achieve an SVR (cure) in 12 weeks with few side
Ombitasvir, paritaprevir and ritonavir co-packaged with dasabuvir tablets (Viekira Pak), is a combination approved in 2014. SVR with this combination is 91%-100%. The combination of elbasvir and grazoprevir (Zepatier) was approved in 2016. SVR with this combination depends on the HCV genotype and whether individual patient factors require the addition of ribavirin. Genotype 1 has a 94%-97% SVR, and SVR is 97%-100% in genotype 4.