Reactive Arthritis - Treatment

What kinds of treatment, therapy, or medication have been effective for your reactive arthritis?

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How is reactive arthritis treated?

Treatment of reactive arthritis is based on where it has become manifest in the body. For joint inflammation, patients are generally initially treated with nonsteroidal anti-inflammatory drugs (NSAIDs). These medications include aspirin, indomethacin (Indocin), tolmetin (Tolectin), sulindac (Clinoril), piroxicam (Feldene), and others. Among their potential side effects are gastrointestinal irritation, including ulceration and bleeding. They should be taken with food to minimize this risk. Corticosteroids, such as prednisone, can be helpful to reduce inflammation and are used in the short-term treatment of inflammation in reactive arthritis. They can be given by mouth or by local injection into the joint. They are also used to decrease tendon inflammation in some forms of tendinitis.

Antibiotics may be prescribed if you still have the infection that triggered reactive arthritis.

Sulfasalazine (Azulfidine) has been shown to be effective in some patients with persistent reactive arthritis. Potential side effects of this sulfa-based medication include sulfa rash reaction and suppression of the bone marrow. Therefore, blood counts are monitored when Azulfidine is used long-term.

For the aggressive inflammation of chronic joint inflammation in reactive arthritis, medications that suppress the immune system, including methotrexate (Rheumatrex, Trexall), are used. Methotrexate can be given orally by injection. It is given on a weekly basis and requires regular monitoring of blood counts and blood liver tests because of potential toxicity to the bone marrow and liver.

Tumor necrosis factor blockers (TNF): The cell protein TNF acts as an inflammatory agent in rheumatoid arthritis. There is some evidence that TNF blockers can also be helpful in reactive arthritis.

Reactive arthritis has been reported in association with HIV infection (AIDS virus). In this context, immune-suppression medicine is generally avoided because of the potential for worsening the HIV disease.

Eye inflammation can be alleviated with anti-inflammatory drops. Some patients with severe iritis require local injections of cortisone to prevent damaging inflammation to the eye, which can lead to blindness.

The inflammation around the penis can be helped by cortisone creams (such as Topicort). When bacteria are discovered in the bowel or urine, antibiotics specific for those bacteria are given.

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