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How is CA 125
CA 125 is usually measured from a venous blood sample. It can also be measured in fluid from the chest or abdominal cavity. The tests currently in use are all
based upon the use of an antibody that is directed against the CA 125 protein (monoclonal antibody technique).
In 1991, an improved version of the test was
introduced and is sometimes denoted as CA 125 - II. The numerical figure of the second generation test results may be higher or lower than a first generation test.
The first generation test is no longer used. When comparing multiple test results over time, it can be important to know which method was used.