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GENERIC NAME: Permethrin

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DRUG CLASS AND MECHANISM: Permethrin is a topical cream used to treat scabies. Permethrin is a neurotoxin that works by paralyzing nerves in respiratory muscles of scabies, causing their death. The FDA approved permethrin in August 1989.



PREPARATIONS: Permethrin is available as a 5% cream in 60 gram tube.

STORAGE: Permethrin cream should be stored at room temperature between 20 C to 25 C (68 F to 77 F).

PRESCRIBED FOR: Permethrin 5% cream is prescribed for the treatment of scabies.

DOSING: For adults and children, the usual dose is a generous amount of cream from head to feet, left on for 8 to 14 hours, then washed with soap and water. This may be repeated in 14 days if necessary.

Safe and effective use of permethrin is not established in pediatric patients younger than 2 months of age.

DRUG INTERACTIONS: There are no significant drug interactions with permethrin.

PREGNANCY: There are no adequate studies done with permethrin to determine safe and effective use in pregnant women.

NURSING MOTHERS: It is not known whether permethrin enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.


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