Peptic Ulcer Disease
Jay W. Marks, MD
Bhupinder Anand, MD
Peptic ulcer facts
- Peptic ulcers are sores in the lining of the stomach or duodenum.
- Peptic ulcer formation is related to H. pylori bacteria in the stomach and nonsteroidal anti-inflammatory medications (NSAIDs) in 50% of patients. For the remaining 50% there are miscellaneous or unknown causes.
- Ulcer pain may not correlate with the presence or severity of ulceration.
- The main symptom of peptic ulcer is upper abdominal pain which can be dull, sharp, or burning. (Bloating and burping are not symptoms of peptic ulcer, and vomiting, poor appetite, and nausea are uncommon symptoms of peptic ulcer.)
- Diagnosis of ulcer is made with upper GI series or endoscopy.
- Treatment of ulcers involves antibiotic combinations along with stomach acid suppression to eradicate H. pylori, eliminating precipitating factors such as NSAIDs and stomach acid suppression with medications alone .
- Complications of ulcers include bleeding, perforation, and blockage of the stomach (gastric obstruction).
- If a person with peptic ulcers smokes or take NSAIDs, the ulcers may recur after treatment.