From Our 2008 Archives

Low HDL Linked to Memory Loss

High Levels of 'Good' Cholesterol May Lower Risk of Dementia, Study Suggests

By Salynn Boyles
WebMD Health News

Reviewed By Elizabeth Klodas, MD, FACC

June 30, 2008 — Low levels of high-density lipoprotein (HDL), or "good" cholesterol, in middle age could increase the risk of developing dementia later in life, new research suggests.

Falling HDL cholesterol levels among study participants in their mid 50s to early 60s predicted memory declines during the same period.

Although poor memory in middle age has not been directly linked to Alzheimer's disease and other forms of dementia in old age, memory decline is key to the diagnosis of these conditions, lead researcher Archana Singh-Manoux, PhD, tells WebMD.

"Our research does not show a link between HDL and dementia," she says. "We looked at cognitive decline in midlife, but it may turn out that this decline is a risk factor for dementia."

HDL, LDL and Memory

Researchers have attempted to study HDL and other lipids like low-density lipoprotein (LDL), total cholesterol, and triglycerides in patients with Alzheimer's and other age-related dementias, but these studies have proven problematic, Singh-Manoux says.

"By the time people are diagnosed they have usually had the disease for many years, and the disease itself may have modified these lipid profiles," she says.

As a result, more and more researchers are focusing on potential risk factors for dementia that present long before the disease is identified.

This was the approach used by Singh-Manoux and colleagues from the University College London.

Their study included 3,673 civil servants enrolled in a British health trial, which included periodic analysis of blood lipid levels and testing for memory declines.

The data analyzed by the researchers were collected at two time periods — when the average age of the participants was 55 and again when they were 61.

Low HDL cholesterol was defined as less than 40 mg/dL, and an HDL level of 60 mg/dL or more was considered high.

During the observation period, declines in HDL were found to be associated with corresponding declines in memory.

At age 61, study participants with low levels of "good" cholesterol had a 53% increased risk of memory loss compared to participants with high HDL levels.

Statins Didn't Help Memory

Total cholesterol and triglyceride levels were not linked with memory declines, and the use of statin drugs did not seem to affect memory loss.

Statins lower LDL but are not very effective for raising HDL. Clinical trials of other drugs that specifically target HDL have so far proven disappointing.

Following a healthy lifestyle — including regular exercise, maintaining a healthy weight, and not smoking — is the best way to raise HDL levels, American Heart Association (AHA) spokeswoman Martha Daviglus, MD, PhD, tells WebMD.

"A healthy lifestyle can make a huge difference for everyone," she says. "We know that lifestyle is key to lowering risk for a whole range of diseases and conditions."

The new findings suggest that making healthy lifestyle choices early on could benefit memory and cognitive function in middle age with the possibility of preventing dementia later in life.

The study appears in the August issue of the AHA journal Arteriosclerosis, Thrombosis and Vascular Biology.

"Total cholesterol and LDL are well established risk factors for heart disease," Singh-Manoux says. "Physicians monitor these levels regularly, but I don't think we pay enough attention to HDL cholesterol. Our results show HDL cholesterol to be important for memory, so physicians and patients should be encouraged to monitor HDL."

SOURCES: Singh-Manoux, A., Arteriosclerosis, Thrombosis and Vascular Biology, August 2008; online edition. Archana Singh-Manoux, PhD, senior researcher, University College London, England. Martha Daviglus, MD, PhD, professor of preventive medicine and medicine, Northwestern University, Chicago; spokeswoman, American Heart Association.

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