From Our 2007 Archives

Preeclampsia Ups Heart Disease, Death

More Heart Disease After High-Blood-Pressure Pregnancy Syndrome

By Daniel J. DeNoon
WebMD Health News

Reviewed By Louise Chang, MD

Nov. 1, 2007 -- Preeclampsia doubles a woman's risk of later heart disease -- perhaps over and above the risk from other factors that contribute to heart disease.

Preeclampsia is a pregnancy syndrome marked by dangerously high blood pressure. In the developed world, 3% to 5% of women develop preeclampsia during their first pregnancy.

During pregnancy, preeclampsia poses risks to both mother and child. But a woman's risk continues long after the child is born. Now a research team led by preeclampsia expert David Williams, MBBS, PhD, FRCP, University College London, calculates these risks.

"Women who have had preeclampsia have a twofold higher risk of heart disease, stroke, and thromboembolism [dangerous blood clots]," Williams tells WebMD.

Williams, medical student Leanne Bellamy, and colleagues analyzed 25 long-term studies of preeclampsia. Their data provided information on 3.5 million women, nearly 200,000 of whom had preeclampsia.

They found that women who had preeclampsia were:

  • 2.16 times more likely to have heart disease within 11.7 years
  • 1.81 times more likely to have a stoke within 10.4 years
  • 1.79 times more likely to have venous thromboembolism (dangerous blood clots)within 4.7 years
  • 1.49 times more likely to die within 14.5 years
  • 3.7 times more likely to have high blood pressure within 14 years
  • No more or less likely to have cancer within 17 years.

An editorial by Laura A. Magee, MD, FRCPC, clinical associate professor of medicine at the University of British Columbia, Canada, accompanies the Williams study.

"The bottom line is this is information women learn about themselves during pregnancy," Magee tells WebMD. "It should give them pause to do something -- to think about their risk and effect change."

Pregnancy as Stress Test

The study findings suggest that heart disease and preeclampsia share many of the same risk factors. But Williams says the data also suggest that the risk from preeclampsia may be independent -- that is, over and above risks such as being overweight or having high cholesterol.

"Is a history of preeclampsia an independent risk factor that adds to a woman's future cardiovascular risk? One of the biggest studies we looked at suggests it is an independent risk," Williams says. "So a middle-aged woman might have her cardiovascular risk calculated from classical risk factors. But if she has a history of preeclampsia, it could be up to a twofold additional risk."

Because many women are young when they give birth, they are at very low risk of having heart disease right away -- even if they have preeclampsia. But pregnancy gives a woman a look into a crystal ball that warns of coming trouble.

"Pregnancy acts as a physical stress test that temporarily draws out her high blood pressure," Williams says. "It goes away after she gives birth. But the woman must not forget she is at risk. If she remembers early enough, she can benefit from lowering her cardiovascular risk."

Pregnancy as Stress Test continued...

"Some women fail this cardiovascular and metabolic stress test which is revealing their future, telling them things about themselves they would know," Magee says. "Having preeclampsia increases your risk of long-term problems -- but it gives you the opportunity early in life to prevent those problems."

Williams and colleagues are now trying to learn exactly what it is about preeclampsia that might add to a woman's risk of heart disease. They are also hoping to learn whether aggressive treatment after -- perhaps with cholesterol-lowering statin drugs or blood-pressure-lowering drugs -- might help lower this risk.

For now, both Williams and Magee agree that lifestyle changes -- not drug treatments -- are the best options for women who've had preeclampsia.

"All women should be following a heart-healthy diet and lifestyle. But it is particularly important for these women," Magee says. "Having a baby turns your life upside down anyway, so if you're making changes, why not make all the right changes?"

The Williams/Bellamy study and Magee's editorial appear in the Nov. 2 online edition of the British Medical Journal.

SOURCES: Bellamy, L. British Medical Journal, Online First edition, Nov. 2, 2007. David Williams, MBBS, PhD, FRCP, consultant obstetric physician, Institute for Women€™s Health, Elizabeth Garrett Anderson Obstetric Hospital, University College London. Laura A. Magee, MD, FRCPC, clinical associate professor, University of British Columbia, Vancouver, Canada.

Reviewed on November 02, 2007
© 2007 WebMD Inc. All rights reserved.





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