Digestion Q&A by Dr. Lee
Yes, it is possible. Endomysial antibodies and anti-tissue transglutaminase antibodies (blood tests for diagnosing celiac disease) are highly reliable In diagnosing celiac disease. An individual with abnormally elevated endomysial and anti-tissue transglutaminase antibodies has a greater than 95% chance of having celiac disease. Anti-gliadin antibodies are less reliable and have a higher rate of false positive tests.
However, I personally have taken care of patients with small bowel biopsies and symptoms of celiac disease, but whose blood tests (endomysial antibodies and anti-tissue transglutaminase antibodies) were normal, such as, false negative tests.
There are two recognized reasons for false negative blood tests for celiac disease:
Thank you for your question.
Last Editorial Review: 12/19/2006