Retroviruses and Opportunistic Update from the CROI National Meeting

Dr. Eric Daar offers perspectives of interest on topics from the 13th Conference on Retroviruses and Opportunistic Infections (held in Denver, Colorado February 5-8, 2006) Conference on Rotaviruses and Opportunistic Infections

Index to the Daily Updates:
Conference (February 5th - 6th Transcript)
Culturing Hepatitis C Virus in vitro
HIV Transmission
Drug-Drug Interactions
Screening for Sexually Transmitted Infections (STIs)
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Conference (February 7th Transcript)
Treatment Interruptions
Maintenance Therapy
Treatment Simplification
Ritonavir (RTV)-Boosted Atazanavir (ATV) in Treatment Nave Subjects
HIV Superinfection
Mother to Child Transmission
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Conference (February 8th Transcript)
Circumcision and HIV Transmission
Tolerability of Antiretroviral Therapy in the Developing World
Cardiovascular Disease and Antiretroviral Therapy
Antiretroviral Therapy in Development
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listen nowListen now Introduction to Conference (MP3 5:23min 861KB)

Hello this is Dr. Eric Daar calling from Denver, Colorado from the 13th Conference on Retroviruses and Opportunistic Infections or CROI 2006.  This has been traditionally now one of the main HIV research meetings of the year.  There are 3800 researchers from around the world who have converged on Denver to present new information on both clinical and laboratory based research as well as behavioral research related to HIV and AIDS.  Numerous important presentations from many investigators around the world including some important opening keynote presentations on the evening of February 5th...

listen nowListen now Day 1 of Conference(MP3 4:05min 861KB

This meeting opened with a Plenary session and keynote lecture on Sunday, February 5th.  The keynote was presented by Dr. James Kern on 25 years of the HIV pandemic, where he described his experience at the CDC in the first reported cases of AIDS  in 1981 in Los Angeles.  He emphasized  the many advances in the following years as well as the obstacles overcome and the obstacles that are left to be overcome both with  prevention, the development of vaccine, and the potential hope for eradication...

listen nowListen now Day 2 of Conference (MP3 4:50min 861KB)

Update on meeting on second full day (February 7th). There were actually a series of world presentations all dealing with the related topic of treatment interruptions. Recently, a great deal of attention came to this area with the announcement of the data safety monitoring board closing one of these very important studies that was presented as a late breaker.  The study was called SMART. It was a study through the CPCRA and the strategy was to determine whether you could take individuals with greater than 350 T cells and randomly assign them to either continue on their current therapy or interrupt their treatment with the plan of them restarting therapy if their CD4 count  should drop to less than 250.  The plan...

listen nowListen now to Summary of Last Day (MP3 8:30min 861KB)

Last day of conference (February 8th).  It has been an extremely exciting day with some very important presentations in the area of complications of antiretroviral therapy and new treatments.  The first presentation was from the CDC describing the experience in Uganda in over a thousand individuals started on antiretroviral therapy for the first time. There has been a major rollout of therapy in the developing world and this one with another report, were one of the largest to describe the tolerability of such therapy. This looked at over 1,000 individuals from 2003-2004 started on standard first line regimen in the developing world...

Conference Mission:

The mission of the Retrovirus Conference is to provide a forum for basic scientists and clinicians to present, discuss, and critique their investigations into the biology and epidemiology of human retroviruses and the diseases they produce with the ultimate goal of translating laboratory and clinical research into progress against the AIDS epidemic.

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