Testicular Cancer: Treatment and Survival (cont.)

Besides lumps, if a man notices any other abnormality--an enlarged testicle, a feeling of heaviness or sudden collection of fluid in the scrotum, a dull ache in the lower abdomen or groin, or enlargement or tenderness of the breasts--he should discuss it with a physician right away. These symptoms can be caused by conditions other than cancer. But only a doctor can tell for sure, and it is critical to seek attention promptly.

Physicians have various methods to help diagnose testicular cancer. Often a physical exam can rule out disorders other than cancer. Imaging techniques can help indicate possible tumors. One such method is ultrasound, which creates a picture from echoes of high-frequency sound waves bounced off internal organs. Malkowicz calls this method "a painless, noninvasive way to check for a mass."

But the only positive way to identify a tumor is for a pathologist to examine a tissue sample under a microscope. Doctors obtain the tissue by removing the entire affected testicle through the groin, a procedure called inguinal orchiectomy. Surgeons do not cut through the scrotum or remove just a part of the testicle, because if cancer is present, a cut through the outer layer of the testicle may cause the disease to spread locally. Besides enabling diagnosis, testicle removal also can prevent further growth of the primary tumor.

Nearly all testicular tumors stem from germ cells, the special sperm-forming cells within the testicles. These tumors fall into one of two types, seminomas or nonseminomas. Other forms of testicular cancer, such as sarcomas or lymphomas, are extremely rare.

Seminomas account for about 40 percent of all testicular cancer and are made up of immature germ cells. Usually, seminomas are slow growing and tend to stay localized in the testicle for long periods. It was a seminoma that struck former Philadelphia Phillies first baseman John Kruk at age 33 in 1994. His right testicle was removed, and doctors say his prognosis is good.

Nonseminomas are a group of cancers that sometimes occur in combination, including choriocarcinoma, embryonal carcinoma, and yolk sac tumors. Nonseminomas arise from more mature, specialized germ cells and tend to be more aggressive than seminomas. According to the American Cancer Society, 60 to 70 percent of patients with nonseminomas have cancer that has spread to the lymph nodes.

Cancer Stages

Physicians measure the extent of the disease by conducting tests that allow the doctor to categorize, or "stage," the disease. These staging tests include blood analyses, imaging techniques, and sometimes additional surgery. Staging allows the doctor to plan the most appropriate treatment for each patient.

There are three stages of testicular cancer:

  • Stage 1--Cancer confined to the testicle.
  • Stage 2--Disease spread to retroperitoneal lymph nodes, located in the rear of the body below the diaphragm, a muscular wall separating the chest cavity from the abdomen.
  • Stage 3--Cancer spread beyond the lymph nodes to remote sites in the body.
Through blood tests, doctors can check for tumor-associated markers, substances often present in abnormal amounts in cancer patients. Comparing levels of markers before and after surgical treatment helps doctors determine if cancer has spread beyond the testicles. Likewise, measuring marker levels before and after chemotherapy treatment can help show how well the chemotherapeutic drugs are working.

FDA has approved a test that checks blood levels of alpha-fetoprotein (AFP) as a tumor-associated marker. Other tests, such as those that gauge levels of beta-human chorionic gonadotropin (bHCG) or lactate dehydrogenase (LDH), are widely used as tumor-associated markers, but FDA has insufficient data to approve these tests.

Imaging techniques provide doctors with pictures of internal organs, giving visual clues to cancer staging. Chest x-rays can tell doctors if disease has spread to the lungs. Lymphangiography allows the lymph nodes to be visualized on an x-ray. CT scans create detailed views of cross sections of the body and can indicate possible tumors at various body sites.

Surgery to remove the retroperitoneal lymph nodes, into which the testicles drain, often is necessary for testicular cancer patients. Doctors examine lymph tissue microscopically to help determine the stage of the disease. Also, removing the tissue helps control further cancer spread.

Cancer Treatment

No one treatment works for all testicular cancers. Seminomas and nonseminomas differ in their tendency to spread, their patterns of spread, and response to radiation therapy. Thus, they often require different treatment strategies, which doctors choose based on the type of tumor and the stage of disease.

Because they are slow growing and tend to stay localized, seminomas generally are diagnosed in stage 1 or 2. Treatment might be a combination of testicle removal, radiation, or chemotherapy. But surgical removal of lymph nodes usually is not necessary for seminoma patients because this type of tumor is what the University of Pennsylvania's Malkowicz calls "exquisitely sensitive" to radiation. Normally directed to the retroperitoneal lymph nodes but sometimes to other lymph nodes, radiation can effectively remove cancer cells there. Stage 3 seminomas are usually treated with multidrug chemotherapy.

Though most nonseminomas are not diagnosed at an early stage, cases confined to the testicle may need no further treatment other than testicle removal. These men must have careful follow-up for at least two years because about 10 percent of stage 1 patients have recurrences, which then are treated with chemotherapy. Stage 2 nonseminoma patients who have had testicle and lymph node removal may also need no further therapy. Some doctors opt for a short course of multidrug chemotherapy for stage 2 patients to reduce the risk of recurrence. Most stage 3 nonseminomas can be cured with drug combinations.