Face Transplants Face Reality (cont.)

Why? The transplanted material would be a kind of a soft mask made of skin and soft tissue. Its final shape would depend on the bone structure of the recipient. That means that the person who got the transplant would have a brand-new face. It would not look like the face of the donor. It would not look like the recipient's old face, either.

"The recipient will not look like the donor or like themselves," Pearlman says. "We are not transplanting the underlying skeleton. So there will be no resemblance whatever. They will look more like someone with reconstruction of a severe burn or devastating cancer. These are people who are not going to be that visibly attractive. Like when a toe is used to replace the thumb. It is not a terribly attractive digit, but it works."

The new face would look better than the skin grafts now used to heal the wounds of people who suffer devastating facial burns or traumas -- if all went well. But there would still be big scars. The new face would not move like a person's original face, says Ira D. Papel, MD, an officer of the American Board of Facial, Plastic, and Reconstructive Surgery Inc. and associate professor at Johns Hopkins University School of Medicine.

"We have a long way to go," Papel says. "It is not just appearance but function: motion, integrating the movement of the skin with movement of the nose, mouth, and eyes. All the senses will be affected - and we have no way of hooking up nerves in a reliable fashion. To try to get normal facial function, it is a wish at this point. Maybe someday it will all be possible. But not yet."

Face Transplants: Serious Surgery for Serious Situations

"The risks are just awesome," Papel tells WebMD. "If a kidney transplant is rejected, you go back on dialysis. If all the skin on your face is rejected, what do you do? If it just sloughs off, what are you left with? That's a horror-movie situation."

There's about a 10% risk that a transplant won't take. Over the next two to five years, the risk of rejection is much higher. Historically, one-third to one-half of transplants eventually are rejected.

That's too much of a risk, says Douglas Hanto, MD, chief of the division of transplantation at Boston's Beth Israel Deaconess Hospital.

"The real question is whether the benefits and expected success rate are worth the long-term immune suppression," Hanto tells WebMD. "Clearly these patients will require life-long immune suppression. If the outcome is not much better than a 30% rejection rate, it will be hard to justify."

There are situations in which face transplants could save lives.

For example, Pearlman suggests, what if some hypothetical child suffered a terrible, slow-spreading cancer of the face? By the time that child became a teen, the tumor would not only have destroyed the face, but would also be life threatening. If, however, a surgeon had the chance to cut away the tumor -- and replace the face -- recovery might be possible.

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