Feature Archive

The Future of Follicles

Science is inching its way to a cure for baldness.

By Lynda Liu
WebMD Feature

If you're a man who is seeing more of your scalp than you'd like, you're not alone. According to the American Academy of Dermatology, two out of three men in this country develop some form of balding. While some cutting-edge treatments in the world of hair renewal are still things of the somewhat distant future, treatments such as medications and hair transplantation surgery are available now. You probably won't become Andre Agassi's hair twin, but you can start filling in your gaps.

Follicles of the Future

Most men who lose their hair have a hereditary condition called androgenic alopecia, says Neil Sadick, M.D., Clinical Associate Professor in the Department of Dermatology at Cornell University Medical College. These men have increased levels of a hormone known as 5(alpha)-reductase, which changes testosterone to dihydrotestosterone (DHT). The DHT in turn causes follicles to sprout shorter and finer hairs before eventually dying out. It also causes the growth phases of hair follicles to become shorter, and the rest phases to be longer.

But researchers are discovering that this rest phase can be shortened. The October 1999 Journal of Clinical Investigation reported that scientists at the Weil Medical College of Cornell University succeeded in nudging hair follicles out of their rest phases -- at least in mice. They used an altered form of cold virus to deliver what they have named the "Sonic hedgehog" gene (after a video-game character), which plays a central role in hair follicle development. This therapy spurred the mice to sprout new hairs, presumably by causing those in the rest phase to enter the growth phase. Researchers say further study is needed before it is known if this therapy could potentially help those with male pattern baldness.