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Tip Sheet: Ulcers and Pain Relievers

Be cautious about taking over-the-counter pain relief drugs if you have an ulcer. Some can worsen your symptoms. These tips will help.

By R. Morgan Griffin
WebMD Feature

Reviewed By Charlotte Grayson

If you have an ulcer, you need to be very careful with over-the-counter pain medicines. Remember: No drug is risk-free. Here are some tips from the experts for using these medicines safely.

  • Avoid Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) if possible. If you have an ulcer, try not to use NSAIDs, such as aspirin or ibuprofen. A non-NSAID pain reliever, like acetaminophen, is a safer choice.
  • Take precautions. If you need to use an NSAID, always take it with milk or food to make it easier on your stomach. To prevent problems, your doctor might recommend:
    • A prescription proton pump inhibitor (like Prilosec, Prevacid, Aciphex, Protonix, and Nexium)
    • High doses of prescription H2 receptor antagonists (like Pepcid, Tagamet, Zantac, and Axid)
    • Cytotec, a drug to protect your stomach lining
  • Look for symptoms. If you have to take an NSAID, know the symptoms of trouble. If you have an increase in abdominal pain, nausea, vomiting, loss of appetite, dark stools, weight loss, or fatigue, get checked out right away.
  • Know the risk factors. A lot of the time, ulcers don't have warning signs. "For many people, internal bleeding is the first sign that they're having a problem with NSAIDs," says Byron Cryer, MD, a spokesman for the American Gastroenterological Association. You can't rely on early symptoms to tell you that something's wrong. Instead, you need to ask your doctor if you are at high risk of having problems. For instance, people who take high doses of NSAIDs or are over 65 are more likely to have problems. If you are at increased risk, take extra precautions.
  • Avoid alcohol. Most pain relievers do not mix with alcohol. If you take an NSAID, including aspirin, just one drink a week can increase your risk of gastrointestinal bleeding. People who have three or more drinks a day should not use these medicines. Combining acetaminophen and alcohol may increase the risks of liver damage.
  • Use as directed. Follow the directions for the recommended dosage. Most painkillers shouldn't be used for more than 10 days. If you're still in pain by that point, see your health care provider.
  • Read the package insert. Admit it: When you buy a bottle of over-the-counter pain reliever, you likely throw out the printed insert along with the empty box. But you really should get in the habit of reading it. Find out what side effects you should look for. Look at the list of possible drug interactions.
  • Read the ingredients of all medicines. Painkillers like aspirin, acetaminophen, and ibuprofen can show up in the most unlikely places. For instance, many over-the-counter medicines for colds also contain doses of pain reliever. So make sure you know what you're getting.