Stopping Sperm in Their Tracks

November 16, 2004 -- An enzyme in sperm has been discovered to be essential for sperm movement. Mice without this enzyme produce sperm that cannot swim toward eggs to fertilize them.

The enzyme is called GAPDS, short for glyceraldehyde 3-phosphate dehydrogenase-S.

GAPDS provides a tempting target for drugmakers since a drug that can block the enzyme could be a new form of male contraception. With it, males could go on the pill, too.

Barbara K. Hecht, Ph.D.
Frederick Hecht, M.D.
Medical Editors,

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Enzyme Essential To Sperm Movement Provides Target for New Contraceptive Approach

A team of researchers has determined that an enzyme in sperm is necessary for sperm movement. Mice bred to lack this enzyme produce sperm that cannot swim toward egg cells to fertilize them.

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