Osteoarthritis: 2004 Perspectives (cont.)


Hyaluronic acid injections into the knee joints of patients with osteoarthritis were reported as effective and safe in relieving pain.

Dr. Shiel's Perspective: While it is frankly not known how these compounds work, they can be effective in relieving pain in the knees of some patients with osteoarthritis. The medication is injected directly into the knees with a series of 3-5 weekly injections.

Botox injected into painful osteoarthritis knee joints was helpful in relieving pain.

Dr. Shiel's Perspective: Yes, you heard it right! This was a small study and will require much extensive research to confirm the significance of Botox in treating knee pain in osteoarthritis.

Etoricoxib (Arcoxia) was presented in 4 studies at the national meeting and shown to be safe and effective in treating gout, osteoarthritis, and ankylosing spondylitis.

Dr. Shiel's Perspective: Etoricoxib (Arcoxia) is a Cox-2 inhibitor that is used in Europe and elsewhere to reduce pain and inflammation of arthritis. This drug is somewhat related to Vioxx, another Cox-2 inhibitor that was withdrawn from the market by Merck because of heart attack and stroke side effects. Etoricoxib (Arcoxia) is awaiting approval for use in the U.S., and while its maker notes that it has been shown to be safe, I believe it will undergo serious scrutiny of longer term studies prior to approval for the U.S. market. The drug is clearly effective for the inflammation of arthritis.