Medical Definition of Tetraethyl lead

Tetraethyl lead: An anti-knock compound added to motor fuel. Also known as tetraethylplumbane, tetraethyl lead has highly adverse effects on human health. It causes lead poisoning.

The History of Tetraethyl Lead

In 1921 three General Motors (GM) engineers -- Charles Kettering, Thomas Midgeley, and Thomas Boyd -- reported success with adding tetraethyl lead to improve engine performance and reduce engine knock. Through the Ethyl corporation, then a GM subsidiary, GM quickly began touting this lead compound as the virtual savior of the American automobile industry. The discovery was indeed extremely important. It paved the way for the development of the high-power, high-compression internal combustion engines.

The first danger sign was the mysterious illness that forced Thomas Midgeley to spend weeks convalescing in the winter of 1923. Midgeley had been experimenting rather recklessly with the various methods of manufacturing tetraethyl lead, and he did not at first realize just how dangerous the substance was in its concentrated liquid state. The deadliness of tetraethyl lead was sadly confirmed in the summer of 1924. Workers engaged in producing the additive fell sick and died at several refineries in New Jersey and Ohio. Banner headlines greeted each new fatality until a total of 15 workers had lost their minds and then their lives.

In 1925, the US Surgeon General temporarily suspended the production and sale of leaded gasoline. He appointed a panel of experts to investigate the recent fatalities that had "occurred in the manufacture and mixing of the concentrated tetraethyl lead." The panel was also asked to weigh "the possible danger" that might arise "from...wide distribution of a lead compound" through its sale as a gasoline additive.

Industry dominated the Surgeon General's investigatory committee, which included only one genuine environmental visionary, Dr. Alice Hamilton of Harvard University. The Coolidge Administration gave the panel just seven months to design, run, and analyze its tests. The committee's final report, published in June 1926, complained of the time constraints under which it had been forced to operate. Seven months was "not sufficient," argued the panel, "to produce detectable symptoms of lead poisoning" in experimental subjects because of the very slow gestation of that toxicological syndrome.

Nevertheless, the Surgeon General's panel ruled that there were "no good grounds for prohibiting the use of ethyl a motor fuel, provided that its distribution and use are controlled by proper regulations." The coming decades of Depression, total war, and post-war boom were hardly conducive to the implementation of "proper regulations" for leaded gasoline. Indeed, no compulsory standards were set for the industry until the early 1970s when EPA began its long, hard struggle to phase down lead levels in US gasoline.

One saturnine prophecy marred the otherwise sanguine 1926 report to the Surgeon General. By 1958 these words were to reverberate with particular resonance down the corridors of time: "It remains possible that, if the use of leaded gasolines becomes widespread, conditions may arise very different from those studied by us which would render its use more of a hazard than would appear to be the case from this investigation. Longer experience may show that even such slight storage of lead as was observed [among human guinea pigs] in these [1925] studies may lead eventually to recognizable lead poisoning or to chronic degenerative diseases of a less obvious character. In view of such possibilities the committee feels that the investigation begun under their direction must not be allowed to lapse.... With the experience obtained and the exact methods now available, it should be possible to follow closely the outcome of a more extended use of this fuel and to determine whether or not it may constitute a menace to the health of the general public after prolonged use or under conditions not now foreseen.... The vast increase in the number of automobiles throughout the country makes the study of all such questions a matter of real importance from the standpoint of public health." Needless to say, this advice fell on deaf ears.

In 1927 the Surgeon General set a voluntary standard for the oil industry to follow in mixing tetraethyl lead with gasoline. This standard -- 3 cubic centimeters per gallon (cc/g) -- corresponded to the maximum then in use among refiners, and thus imposed no real restraint. Even without prodding, however, the industry did take giant strides toward instituting safer working conditions in oil refineries, thereby protecting individual laborers in the microcosm of the workplace.

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