Exanta, New Anticoagulant Launched


Statement of Policy: As a general rule, MedicineNet.com does not publish press releases from companies or private interest groups. However, we have made an exception here because Exanta is the first oral anticoagulant since the introduction of warfarin almost 60 years ago. Exanta has not been approved for use in the United States.

FIRST LAUNCH FOR ASTRAZENECA'S EXANTA™ (XIMELAGATRAN): THE FIRST ORAL ANTICOAGULANT IN NEW CLASS OF DIRECT THROMBIN INHIBITORS (DTIS)

Exanta™ (ximelagatran), a new anticoagulant and the first oral treatment in the new class of direct thrombin inhibitors (DTIs), is launched today in Germany in its first indication: the prevention of venous thromboembolic events (VTE) in elective hip or knee replacement surgery (orthopaedic surgery). Exanta is the first oral anticoagulant since the introduction of warfarin almost 60 years ago, and is the product of over 20 years' research and development at AstraZeneca. It was developed to provide a solution to the significant unmet medical need for a new, predictable and well-tolerated oral therapy for patients at risk of thrombosis, one of the major causes of cardiovascular morbidity and mortality in the developed world.

The prevention of VTE in orthopaedic surgery is an important proof of principle indication for Exanta and follows the successful completion of the E.U. Mutual Recognition Process for this indication in May 2004. Patients are particularly at risk of thrombosis following orthopaedic surgery, with more than half developing VTE in the absence of preventative anticoagulant treatment. Whilst effective treatments are available, no treatment regimen to date has successfully balanced efficacy and bleeding risk with oral dosing.