Definition of MEF2A
MEF2A: A transcription factor that participates in vascular development. MEF2A is a member of the myocyte enhancer factor-2 (MEF2) family of transcription factors. Messenger RNA (mRNA) from MEF2A has been detected in blood vessels during early embryogenesis. The gene for MEF2A is located on chromosome 15q26.
A heritable deletion within the MEF2A gene that results in the loss of 7 amino acids appears responsible for an autosomal dominant form of coronary artery disease. The deletion alters the cellular distribution of the MEF2A protein and may prevent its function as a vascular transcription factor. It remains to be seen if the MEF2A pathway plays a role in the common form of coronary artery disease resulting from atherosclerosis.
MEF2A is also known as MADS box transcription enhancer factor 2, polypeptide A.
Last Editorial Review: 6/14/2012
Back to MedTerms online medical dictionary A-Z List
Need help identifying pills and medications?
- Allergic Skin Disorders
- Bacterial Skin Diseases
- Bites and Infestations
- Diseases of Pigment
- Fungal Skin Diseases
- Medical Anatomy and Illustrations
- Noncancerous, Precancerous & Cancerous Tumors
- Oral Health Conditions
- Papules, Scales, Plaques and Eruptions
- Scalp, Hair and Nails
- Sexually Transmitted Diseases (STDs)
- Vascular, Lymphatic and Systemic Conditions
- Viral Skin Diseases
- Additional Skin Conditions