DOCTOR'S VIEW ARCHIVE
Psoriasis, Lupus,Rheumatoid ArthritisShare One GeneFrederick Hecht, M.D.
Medical Editor: Barbara Hecht, Ph.D.
Nov. 11, 2000 -- Changes in one gene have been discovered that are shared by three common autoimmune diseases -- the skin condition psoriasis as well as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). The genetic changes involve a gene called Runx-1.
What is Runx-1?
Runx-1 stands for runt-related transcription factor 1. Runx-1 is also called AML1 because it is also altered in a form of acute myeloid leukemia, but that is a very different story, one to be told another time.