DOCTOR'S VIEW ARCHIVE
Psoriasis, Lupus,Rheumatoid ArthritisShare
Medical Author: Frederick Hecht, M.D.
Medical Editor: Barbara Hecht, Ph.D.
Nov. 11, 2000 -- Changes in one gene have been discovered that are shared by
three common autoimmune
diseases -- the skin condition psoriasis as well as systemic lupus erythematosus
(SLE) and rheumatoid arthritis (RA). The genetic
changes involve a gene called Runx-1.
What is Runx-1?
Runx-1 is a protein that acts as a transcription factor. It controls when
genes are switched on or off. Runx-1 does so by binding to regulatory sequences
-- specific sequences of DNA -- that are close to the genes they regulate. These
DNA sequences, called Runx-1 binding sites, are scattered throughout the human
genome, wherever there is a gene
under the control of Runx-1.